Details:

Alternative Title:
Nat Commun
Publisher's site:
http://dx.doi.org/10.1038/ncomms14446
Personal Author:
Schuh, Amy J. ; Amman, Brian R. ; Jones, Megan E. B. ; Sealy, Tara K. ; Uebelhoer, Luke S. ; ... More +
Schuh, Amy J. ; Amman, Brian R. ; Jones, Megan E. B. ; Sealy, Tara K. ; Uebelhoer, Luke S. ; Spengler, Jessica R. ; Martin, Brock E. ; Coleman-McCray, Jo Ann D. ; Nichol, Stuart T. ; Towner, Jonathan S. Less -
Description:
The Egyptian rousette bat (ERB) is a natural reservoir host for Marburg virus (MARV); however, the mechanisms by which MARV is transmitted bat-to-bat and to other animals are unclear. Here we co-house MARV-inoculated donor ERBs with naive contact ERBs. MARV shedding is detected in oral, rectal and urine specimens from inoculated bats from 5-19 days post infection. Simultaneously, MARV is detected in oral specimens from contact bats, indicating oral exposure to the virus. In the late study phase, we provide evidence that MARV can be horizontally transmitted from inoculated to contact ERBs by finding MARV RNA in blood and oral specimens from contact bats, followed by MARV IgG antibodies in these same bats. This study demonstrates that MARV can be horizontally transmitted from inoculated to contact ERBs, thereby providing a model for filovirus maintenance in its natural reservoir host and a potential mechanism for virus spillover to other animals.
Subjects:
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Animals Antibodies, Viral Chiroptera Disease Models, Animal Disease Reservoirs Female Filoviridae Immunoglobulin G Male Marburgvirus Marburg Virus Disease RNA, Viral Virus Shedding
Source:
Nat Commun. 2017; 8.
Pubmed ID:
28194016
Pubmed Central ID:
PMC5316840
Document Type:
Journal Article
Place as Subject:
Egypt
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:78b19ce7ee2d7b9af6061d7eee8fcade8d726b3cc9a67edace372136b612a882
Download URL:
https://stacks.cdc.gov/view/cdc/44406/cdc_44406_DS1.pdf
File Type:

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