Details:

Alternative Title:
Nat Commun
Publisher's site:
http://dx.doi.org/10.1038/ncomms14446
Personal Author:
Schuh, Amy J. ; Amman, Brian R. ; Jones, Megan E. B. ; Sealy, Tara K. ; Uebelhoer, Luke S. ; ... More +
Schuh, Amy J. ; Amman, Brian R. ; Jones, Megan E. B. ; Sealy, Tara K. ; Uebelhoer, Luke S. ; Spengler, Jessica R. ; Martin, Brock E. ; Coleman-McCray, Jo Ann D. ; Nichol, Stuart T. ; Towner, Jonathan S. ; Less -
Description:
The Egyptian rousette bat (ERB) is a natural reservoir host for Marburg virus (MARV); however, the mechanisms by which MARV is transmitted bat-to-bat and to other animals are unclear. Here we co-house MARV-inoculated donor ERBs with naive contact ERBs. MARV shedding is detected in oral, rectal and urine specimens from inoculated bats from 5-19 days post infection. Simultaneously, MARV is detected in oral specimens from contact bats, indicating oral exposure to the virus. In the late study phase, we provide evidence that MARV can be horizontally transmitted from inoculated to contact ERBs by finding MARV RNA in blood and oral specimens from contact bats, followed by MARV IgG antibodies in these same bats. This study demonstrates that MARV can be horizontally transmitted from inoculated to contact ERBs, thereby providing a model for filovirus maintenance in its natural reservoir host and a potential mechanism for virus spillover to other animals.
Subject:
[+]
Animals
Antibodies, Viral
Chiroptera
Disease Models, Animal
Disease Reservoirs
Female
Filoviridae
Immunoglobulin G
Male
Marburgvirus
Marburg Virus Disease
RNA, Viral
Virus Shedding

Source:
Nat Commun. 2017 ; 8.;
Pubmed ID:
28194016
Pubmed Central ID:
PMC5316840
Document Type:
Journal Article ;
Place as Subject:
Egypt ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:78b19ce7ee2d7b9af6061d7eee8fcade8d726b3cc9a67edace372136b612a882
File Type:

Supporting Files

• 	ncomms14446-f5.gif	gif
  	ncomms14446-f5.jpg	jpeg
  	ncomms14446-f6.gif	gif
  	ncomms14446-f6.jpg	jpeg
  	ncomms14446-s1.pdf	pdf
  	ncomms14446-s2.pdf	pdf
  	ncomms14446.nxml	bin
  	ncomms14446-f1.gif	gif
  	ncomms14446-f1.jpg	jpeg
  	ncomms14446-f2.gif	gif
  	ncomms14446-f2.jpg	jpeg
  	ncomms14446-f3.gif	gif
  	ncomms14446-f3.jpg	jpeg
  	ncomms14446-f4.gif	gif
  	ncomms14446-f4.jpg	jpeg

More +