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SPECIFIC BLOOD ABSORPTION PARAMETERS FOR 239PUO2 AND 238PUO2 NANOPARTICLES AND IMPACTS ON BIOASSAY INTERPRETATION
  • Published Date:
    Mar 23 2016
  • Source:
    Radiat Prot Dosimetry. .


Public Access Version Available on: September 23, 2017 information icon
Please check back on the date listed above.
Details:
  • Pubmed ID:
    27009243
  • Pubmed Central ID:
    PMC5322225
  • Description:
    Specific absorption parameters for(239)PuO2and(238)PuO2have been determined based on available biokinetic data from studies in rodents, and the impacts of these parameters on bioassay interpretation and dosimetry after inhalation of nanoPuO2materials have been evaluated. Calculations of activities after an acute intake of nanoparticles of(239)PuO2and(238)PuO2are compared with the corresponding calculations using standard default absorption parameters using the International Commission on Radiological Protection (ICRP) 66 respiratory tract model. Committed effective doses are also evaluated and compared. In this case, it was found that interpretation of bioassay measurements with the assumption that the biokinetic behaviour of PuO2nanoparticles is the same as that of micrometre-sized particles can result in an overprediction of the committed effective dose by two orders of magnitude. Although in this case the use of the default assumptions (5 ┬Ám AMAD, Type S) for assessing dose following inhalation exposure to airborne PuO2nanoparticles appears to be conservative, the evaluation of situations involving PuO2nanoparticles that may have different particle size and solubility properties should prudently follow the ICRP recommendation to obtain and use additional, material-specific information whenever possible.

  • Document Type:
  • Collection(s):
  • Funding:
    CC999999/Intramural CDC HHS/United States
  • Supporting Files:
    No Additional Files
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