Details:

Alternative Title:
Medicine (Baltimore)
Personal Author:
Wang, Shiwen ; Wang, Tongzhan ; Zhang, Wenqiang ; Liu, Xiaolin ; Wang, Xiaofang ; ... More +
Wang, Shiwen ; Wang, Tongzhan ; Zhang, Wenqiang ; Liu, Xiaolin ; Wang, Xiaofang ; Wang, Haiyan ; He, Xiaozhou ; Zhang, Shunxian ; Xu, Shuhui ; Yu, Yang ; Jia, Xingbing ; Wang, Maolin ; Xu, Aiqiang ; Ma, Wei ; Amin, Minal M. ; Bialek, Stephanie R. ; Dollard, Sheila C. ; Wang, Chengbin Less -
Description:
Congenital cytomegalovirus (CMV) infection is the leading viral cause of birth defects and developmental disabilities in developed countries. However, CMV seroprevalence and burden of congenital CMV infection are not well defined in China.Cohort of newborns from 5 birthing hospitals in 2 counties of Shandong Province, China, were enrolled from March 2011 to August 2013. Dried blood spots (DBS) and saliva were collected within 4 days after birth for IgG testing for maternal seroprevalence and real-time PCR testing for congenital CMV infection, respectively.Among 5020 newborns tested for CMV IgG, 4827 were seropositive, resulting in CMV maternal seroprevalence of 96.2% (95% confidence interval [CI]:95.6%-96.7%). Of the 10,933 newborns screened for congenital CMV infection, 75 had CMV detected, resulting in an overall prevalence of 0.7% (95% CI: 0.5%-0.9%), with prevalences of 0.4% (14/3995), 0.6% (66/10,857), and 0.7% (52/7761) for DBS, wet saliva, and dried saliva specimens screened, respectively. Prevalence of congenital CMV infection decreased with increasing maternal age (0.9%, 0.6%, and 0.3% among newborns delivered from mothers aged 16-25, 26-35, and >35 years, respectively; P = 0.03), and was higher among preterm infants than full term infants (1.3% vs 0.6%, P = 0.04), infants with intrauterine growth restriction (IUGR) than those without (1.8% vs 0.7%, P = 0.03), and twins or triplets than singleton pregnancies (2.8% vs 0.7%, P = 0.04). None of the 75 newborns exhibited symptomatic congenital CMV infection, and there was no difference in clinical characteristics and newborn hearing screening results between infants with and without congenital CMV infection at birth.Congenital CMV infection prevalence was lower and the clinical manifestations were milder in this relatively developed region of China compared to populations from other countries with similarly high maternal seroprevalence. Follow-up on children with congenital CMV infection will clarify the burden of disabilities from congenital CMV infection in China.
Subject:
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Adolescent
Adult
Antibodies, Viral
Cohort Studies
Cytomegalovirus
Cytomegalovirus Infections
Female
Fetal Diseases
Humans
Immunoglobulin G
Infant, Newborn
Male
Maternal Age
Pregnancy
Pregnancy Complications, Infectious
Prevalence
Real-Time Polymerase Chain Reaction
Research Article
Saliva
Seroepidemiologic Studies
Young Adult

Source:
Medicine (Baltimore). 96(5).
Pubmed ID:
28151899
Pubmed Central ID:
PMC5293462
Document Type:
Journal Article
Place as Subject:
China
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9ed2397c82b4ada59761d0ac060d8708053a77a49614f75b168147939c8d9b74
File Type:

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