Details:

Alternative Title:
Int J Tuberc Lung Dis
Personal Author:
Hirsch-Moverman, Y. ; Shrestha-Kuwahara, R. ; Bethel, J. ; Blumberg, H. M. ; Venkatappa, T. K. ; ... More +
Hirsch-Moverman, Y. ; Shrestha-Kuwahara, R. ; Bethel, J. ; Blumberg, H. M. ; Venkatappa, T. K. ; Horsburgh, C. R. ; Colson, P. W. ; Less -
Corporate Authors:
for the Tuberculosis Epidemiologic Studies Consortium (TBESC) ;
Description:
OBJECTIVES To assess latent tuberculous infection (LTBI) treatment completion rates in a large prospective US/Canada multisite cohort and identify associated risk factors. METHODS This prospective cohort study assessed factors associated with LTBI treatment completion through interviews with persons who initiated treatment at 12 sites. Interviews were conducted at treatment initiation and completion/cessation. Participants received usual care according to each clinic’s procedure. Multivariable models were constructed based on stepwise assessment of potential predictors and interactions. RESULTS Of 1515 participants initiating LTBI treatment, 1323 had information available on treatment completion; 617 (46.6%) completed treatment. Baseline predictors of completion included male sex, foreign birth, not thinking it would be a problem to take anti-tuberculosis medication, and having health insurance. Participants in stable housing who received monthly appointment reminders were more likely to complete treatment than those without stable housing or without monthly reminders. End-of-treatment predictors of non-completion included severe symptoms and the inconvenience of clinic/pharmacy schedules, barriers to care and changes of residence. Common reasons for treatment non-completion were patient concerns about tolerability/toxicity, appointment conflicts, low prioritization of TB, and forgetfulness. CONCLUSIONS Less than half of treatment initiators completed treatment in our multisite study. Addressing tangible issues such as not having health insurance, toxicity concerns, and clinic accessibility could help to improve treatment completion rates.
Subject:
[+]
Adolescent
Adult
Canada
Female
Follow-Up Studies
Health Knowledge, Attitudes, Practice
Humans
Isoniazid
Latent Tuberculosis
Male
Middle Aged
Multivariate Analysis
Patient Compliance
Prospective Studies
Regression Analysis
Risk Factors
Young Adult

Source:
Int J Tuberc Lung Dis. 19(1):31-38
Pubmed ID:
25519787
Pubmed Central ID:
PMC5296762
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ;
Place as Subject:
Canada ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7cc5720dde39436d99f2e47c5b0bd056e5b005b7a3dcc08c52b920c14a61bcad
File Type:

Supporting Files

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