Gender- and Race-Specific Metabolic Score and Cardiovascular Disease Mortality in Adults: A Structural Equation Modeling Approach—United States, 1988–2006

Details

• Alternative Title:
  Obesity (Silver Spring)
• Personal Author:
  Mercado, Carla I. ; Yang, Quanhe ; Ford, Earl S. ; Gregg, Edward ; Valderrama, Amy L.
• Description:
  Objective
  
  Consider all metabolic syndrome (MetS) components [systolic (SBP) and diastolic (DBP) blood pressures, waist circumference, HDL cholesterol, triglycerides (TG), and fasting glucose] and gender/race differential risk when assessing cardiovascular disease (CVD) risk.
  
  Methods
  
  We estimated a gender- and race-specific continuous MetS score using structural equation modeling and tested its association with CVD mortality using data from National Health and Nutrition Examination Survey III linked with the National Death Index. Cox proportional hazard regression tested the association adjusted for sociodemographic and behavior characteristics.
  
  Results
  
  For men, continuous MetS components associated with CVD mortality were SBP (hazard ratio =1.50, 95% confidence interval =1.14–1.96), DBP (1.48, 1.16–1.90), and TG (1.15, 1.12–1.16). In women, SBP (1.44, 1.27–1.63) and DBP (1.24, 1.02–1.51) were associated with CVD mortality. MetS score was not significantly associated with CVD mortality in men; but significant associations were found for all women (1.34, 1.06–1.68), non-Hispanic white women (1.29, 1.01–1.64), non-Hispanic black women (2.03, 1.12–3.69), and Mexican-American women (3.57, 2.21–5.76). Goodness-of-fit and concordance were overall better for models with the MetS score than MetS (yes/no).
  
  Conclusions
  
  When assessing CVD mortality risk, MetS score provided additional information than MetS (yes/no).
  
  
• Subjects:
  Adolescent Adult Aged Cardiovascular Diseases Female Gender Identity History, 20th Century History, 21st Century Humans Male Metabolic Syndrome X Middle Aged Nutrition Surveys Racial Groups Risk Factors Young Adult

  More +
• Source:
  Obesity (Silver Spring). 23(9):1911-1919.
• Pubmed ID:
  26308480
• Pubmed Central ID:
  PMC5295163
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  23
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c945ab93937f5421d52eb45826be9e8d29e69ede6489cce192103f4f7fa6720e
• Download URL:
  https://stacks.cdc.gov/view/cdc/44087/cdc_44087_DS1.pdf
• File Type:
  [PDF - 380.81 KB ]