Associations of Serum Concentrations of 25-Hydroxyvitamin D and Parathyroid Hormone With Surrogate Markers of Insulin Resistance Among U.S. Adults Without Physician-Diagnosed Diabetes: NHANES, 2003–2006

Details

• Alternative Title:
  Diabetes Care
• Personal Author:
  Zhao, Guixiang ; Ford, Earl S. ; Li, Chaoyang
• Description:
  OBJECTIVE
  
  To examine whether concentrations of serum 25-hydroxyvitamin D (25[OH]D) and parathyroid hormone (PTH) are associated with surrogate markers of insulin resistance (IR) in U.S. adults without physician-diagnosed diabetes.
  
  RESEARCH DESIGN AND METHODS
  
  Cross-sectional data (n = 3,206) from the National Health and Nutrition Examination Survey (NHANES) 2003–2006 were analyzed.
  
  RESULTS
  
  The age-adjusted prevalence of hyperinsulinemia, high homeostasis model assessment-IR, high GHb, and fasting and 2-h hyperglycemia decreased linearly across quintiles of 25(OH)D but increased linearly across quintiles of PTH (except for a quadratic trend for fasting hyperglycemia). After extensive adjustment for potential confounders, the relationships between 25(OH)D and the markers of IR and 2-h hyperglycemia persisted. Only hyperinsulinemia was positively associated with PTH (P < 0.05).
  
  CONCLUSIONS
  
  Among U.S. adults without physician-diagnosed diabetes, low concentrations of serum 25(OH)D were associated with markers of IR. The role of PTH in IR deserves further investigation.
  
  
• Subjects:
  Adult Biological Markers Cross-Sectional Studies Diabetes Mellitus Humans Hyperglycemia Hyperinsulinism Insulin Resistance Nutrition Surveys Original Research Parathyroid Hormone Physicians Prevalence Vitamin D Young Adult

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• Source:
  Diabetes Care. 33(2):344-347.
• Document Type:
  Journal Article
• Volume:
  33
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:70bfb6b068150be2bc63a15575bc38a7480d3c40df68dd19c6938ea37c1f2df3
• Download URL:
  https://stacks.cdc.gov/view/cdc/4406/cdc_4406_DS1.pdf
• File Type:
  [PDF - 67.71 KB ]