Details:

Alternative Title:
Cancer
Publisher's site:
http://dx.doi.org/10.1002/cncr.30190
Personal Author:
Drescher, Charles W. ; Beatty, J. David ; Resta, Robert ; Andersen, M Robyn ; Watabayashi, Kate ; ... More +
Drescher, Charles W. ; Beatty, J. David ; Resta, Robert ; Andersen, M Robyn ; Watabayashi, Kate ; Thorpe, Jason ; Hawley, Sarah ; Purkey, Hannah ; Chubak, Jessica ; Hanson, Nancy ; Buist, Diana S.M. ; Urban, Nicole Less -
Description:
Background

Guidelines recommend genetic counseling and testing for women with a pedigree suggestive of an inherited susceptibility for ovarian cancer. We evaluated the effect of referral to genetic counseling on genetic testing and prophylactic oophorectomy via a randomized controlled trial.

Methods

Data from an electronic mammography reporting system identified 12,919 women with a pedigree including breast cancer, of whom 625 were identified as high risk for inherited susceptibility to ovarian cancer using a risk assessment questionnaire. Of these, 458 women provided informed consent and were randomized 1:1 to intervention consisting of a genetic counseling referral (n=228) or standard clinical care (n=230).

Results

Participants were predominantly aged 45 to 65; 30% and 20% reported a personal history of breast cancer or a family history of ovarian cancer, respectively. Eighty-five percent of women in the intervention group participated in a genetic counseling session. Genetic testing was reported by 74 (33%) and 20 (9%) women in the intervention and control arms (p<0.005) respectively. Five women in the intervention arm and two women in the control arm were identified as germline mutation carriers. Ten women in the intervention arm and three women in the control arm underwent prophylactic BSO (p<0.05).

Conclusion

Routine referral of women at high risk for ovarian cancer to genetic counseling promotes genetic testing and prophylactic surgery. Our findings from a randomized controlled trial demonstrate the value of implementing strategies targeting women at high risk for ovarian cancer to ensure they are offered access to recommended care.


Subject:
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Article Genetic Counseling Ovarian Cancer Referral And Consultation Risk Assessment And Genetic Testing Surgical Prevention
Source:
Cancer. 122(22):3509-3518.
Pubmed ID:
27447168
Pubmed Central ID:
PMC5253334
Document Type:
Journal Article
Funding:
1R18DP001142/Centers for Disease Control and Prevention/ ; P50CA083636/National Institutes of Health/National Cancer Institute/ ; P50 CA083636/CA/NCI NIH HHS/United States ; R18 DP001142/DP/NCCDPHP CDC HHS/United States
1R18DP001142/Centers for Disease Control and Prevention/ ; P50CA083636/National Institutes of Health/National Cancer Institute/ ; P50 CA083636/CA/NCI NIH HHS/United States ; R18 DP001142/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4f962d9fb0afaa670dfbf32a2b801d18e7dd14960d36d74b9e318af691e67978
Download URL:
https://stacks.cdc.gov/view/cdc/43933/cdc_43933_DS1.pdf
File Type:

Supporting Files

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