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Comparison of Bruch's Membrane Opening-Minimum Rim Width among Those with Normal Ocular Health by Race
  • Published Date:
    Nov 05 2016
  • Source:
    Am J Ophthalmol. 174:113-118.


Public Access Version Available on: February 01, 2018 information icon
Please check back on the date listed above.
Details:
  • Pubmed ID:
    27825982
  • Pubmed Central ID:
    PMC5253316
  • Description:
    Purpose

    To examine if racial differences in Bruch's membrane opening-minimum rim width (BMO-MRW) in spectral domain optical coherence tomography (SDOCT) exist, specifically between people of African descent (AD) and European descent (ED) in normal ocular health.

    Design

    Cross-sectional study

    Methods

    Patients presenting for a comprehensive eye exam at retail-based primary eye clinics were enrolled based on ≥1 of the following at-risk criteria for glaucoma: AD aged ≥ 40 years, ED aged ≥50 years, diabetes, family history of glaucoma, and/or preexisting diagnosis of glaucoma. Participants with normal optic nerves on exam received SDOCT of the optic nerve head (24 radial scans). Global and regional (temporal, superotemporal, inferotemporal, nasal, superonasal, and inferonasal) BMO-MRW were measured and compared by race using generalized estimating equations. Models were adjusted for age, gender, and BMO area.

    Results

    SDOCT scans from 269 eyes (148 participants) were included in the analysis. Mean global BMO-MRW declined as age increased. After adjusting for age, gender, and BMO area, there was not a statistically significant difference in mean global BMO-MRW by race (P = 0.60). Regionally, the mean BMO-MRW was lower in the crude model among AD eyes in the temporal, superotemporal, and nasal regions and higher in the inferotemporal, superonasal, and inferonasal regions. However, in the adjusted model, these differences were not statistically significant.

    Conclusions

    BMO-MRW was not statistically different between those of AD and ED. Race-specific normative data may not be necessary for the deployment of BMO-MRW in AD patients.

  • Document Type:
  • Collection(s):
  • Funding:
    K23 EY025724/EY/NEI NIH HHS/United States
    U58 DP004061/DP/NCCDPHP CDC HHS/United States
  • Supporting Files:
    No Additional Files
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