Details:

Alternative Title:
Am J Ophthalmol
Publisher's site:
http://dx.doi.org/10.1016/j.ajo.2016.10.022
Personal Author:
Rhodes, Lindsay A. ; Huisingh, Carrie E. ; Quinn, Adam E. ; McGwin, Gerald ; LaRussa, Frank ; ... More +
Rhodes, Lindsay A. ; Huisingh, Carrie E. ; Quinn, Adam E. ; McGwin, Gerald ; LaRussa, Frank ; Box, Daniel ; Owsley, Cynthia ; Girkin, Christopher A. Less -
Description:
Purpose

To examine if racial differences in Bruch's membrane opening-minimum rim width (BMO-MRW) in spectral domain optical coherence tomography (SDOCT) exist, specifically between people of African descent (AD) and European descent (ED) in normal ocular health.

Design

Cross-sectional study

Methods

Patients presenting for a comprehensive eye exam at retail-based primary eye clinics were enrolled based on ≥1 of the following at-risk criteria for glaucoma: AD aged ≥ 40 years, ED aged ≥50 years, diabetes, family history of glaucoma, and/or preexisting diagnosis of glaucoma. Participants with normal optic nerves on exam received SDOCT of the optic nerve head (24 radial scans). Global and regional (temporal, superotemporal, inferotemporal, nasal, superonasal, and inferonasal) BMO-MRW were measured and compared by race using generalized estimating equations. Models were adjusted for age, gender, and BMO area.

Results

SDOCT scans from 269 eyes (148 participants) were included in the analysis. Mean global BMO-MRW declined as age increased. After adjusting for age, gender, and BMO area, there was not a statistically significant difference in mean global BMO-MRW by race (P = 0.60). Regionally, the mean BMO-MRW was lower in the crude model among AD eyes in the temporal, superotemporal, and nasal regions and higher in the inferotemporal, superonasal, and inferonasal regions. However, in the adjusted model, these differences were not statistically significant.

Conclusions

BMO-MRW was not statistically different between those of AD and ED. Race-specific normative data may not be necessary for the deployment of BMO-MRW in AD patients.


Subject:
[+]
Adult
Bruch Membrane
Cross-Sectional Studies
Female
Follow-Up Studies
Glaucoma
Humans
Incidence
Male
Middle Aged
Optic Disk
Racial Groups
Reference Values
Tomography, Optical Coherence

Source:
Am J Ophthalmol. 174:113-118.
Pubmed ID:
27825982
Pubmed Central ID:
PMC5253316
Document Type:
Journal Article
Funding:
K23 EY025724/EY/NEI NIH HHS/United States ; U58 DP004061/DP/NCCDPHP CDC HHS/United States
K23 EY025724/EY/NEI NIH HHS/United States ; U58 DP004061/DP/NCCDPHP CDC HHS/United States Less -
Place as Subject:
Alabama
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ef7d2c14b7d903cc80d834fbc960a43b653be8c9f196e14476e5e62f33457437
File Type:

Supporting Files

• 	nihms-828260.nxml	xml
  	nihms-828260-f0001.gif	gif
  	nihms-828260-f0001.jpg	jpeg
  	nihms-828260-f0002.gif	gif
  	nihms-828260-f0002.jpg	jpeg
  	nihms-828260-f0003.gif	gif
  	nihms-828260-f0003.jpg	jpeg
  	nihms-828260-f0004.gif	gif
  	nihms-828260-f0004.jpg	jpeg

More +