Pre-diagnostic breastfeeding, adiposity and mortality among parous Hispanic and non-Hispanic white women with invasive breast cancer: the Breast Cancer Health Disparities Study

Details

• Alternative Title:
  Breast Cancer Res Treat
• Personal Author:
  Connor, Avonne E. ; Visvanathan, Kala ; Baumgartner, Kathy B. ; Baumgartner, Richard N. ; Boone, Stephanie D. ; Hines, Lisa M. ; Wolff, Roger K. ; John, Esther M. ; Slattery, Martha L.
• Description:
  Background
  
  U.S. Hispanic women have high rates of parity, breastfeeding and obesity. It is unclear whether these reproductive factors are associated with breast cancer (BC) mortality. We examined the associations between breastfeeding, parity, adiposity and BC-specific and overall mortality in Hispanic and non-Hispanic white (NHW) BC cases.
  
  Methods
  
  The study population included 2,921 parous women (1,477 Hispanics, 1,444 NHWs) from the Breast Cancer Health Disparities Study with invasive BC diagnosed between 1995 and 2004. Information on reproductive history and lifestyle factors was collected by in-person interview. Overall and stratified Cox proportional hazard regression models by ethnicity, parity, and body mass index (BMI) at age 30 years were used to calculate hazard ratios (HR) and 95% confidence intervals (CI).
  
  Results
  
  After a median follow-up time of 11.2 years, a total of 679 deaths occurred. Pre-diagnostic breastfeeding was associated with a 16% reduction in mortality (HR, 0.84; 95% 0.72-0.99) irrespective of ethnicity. Parity significantly modified the association between breastfeeding duration and mortality (p-interaction= 0.05), with longer breastfeeding duration associated with lower risk among women who had ≤ 2 births (p-trend= 0.02). Breastfeeding duration was associated with reduced risk of both BC-specific and overall mortality among women with BMI < 25 kg/m2, while positive associations were observed among women with BMI ≥ 25 kg/m2 (p-interactions < 0.01).
  
  Conclusion
  
  Pre-diagnostic breastfeeding was inversely associated with risk of mortality after BC, particularly in women of low parity or normal BMI. These results provide another reason to encourage breastfeeding and weight management among young women.
  
  
• Subjects:
  Adiposity Adult Aged Aged, 80 And Over Breast Feeding Breast Neoplasms Case-Control Studies Cause Of Death Female Healthcare Disparities Humans Middle Aged Neoplasm Invasiveness Neoplasm Staging Parity Population Surveillance Risk Factors SEER Program White People Young Adult

  More +
• Source:
  Breast Cancer Res Treat. 161(2):321-331.
• Pubmed ID:
  27837379
• Pubmed Central ID:
  PMC5226868
• Document Type:
  Journal Article
• Funding:
  R01 CA078552/CA/NCI NIH HHS/United States ; HHSN261201000036C/CA/NCI NIH HHS/United States ; R01 CA078762/CA/NCI NIH HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States ; R01 CA078802/CA/NCI NIH HHS/United States ; R01 CA078682/CA/NCI NIH HHS/United States ; R01 CA140002/CA/NCI NIH HHS/United States ; K12 HD085845/HD/NICHD NIH HHS/United States ; R01 CA063446/CA/NCI NIH HHS/United States
• Volume:
  161
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:966ec1f0e5cd852ae82d97aa14ea760f19c14e75423a8ec703aec18ebbe9f242
• Download URL:
  https://stacks.cdc.gov/view/cdc/43823/cdc_43823_DS1.pdf
• File Type:
  [PDF - 125.99 KB ]