Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis

Details

• Alternative Title:
  Am J Trop Med Hyg
• Personal Author:
  Tan, Kathrine R. ; Magill, Alan J. ; Parise, Monica E. ; Arguin, Paul M.
• Description:
  Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic (liver stage of Plasmodium) drug and a slow acting blood schizontocidal agent highly effective for the prevention of malaria. When used in conjunction with a fast acting schizontocidal agent, it is also highly effective for malaria treatment. Doxycycline is especially useful as a prophylaxis in areas with chloroquine and multidrug-resistant Plasmodium falciparum malaria. Although not recommended for pregnant women and children < 8 years of age, severe adverse events are rarely reported for doxycycline. This report examines the evidence behind current recommendations for the use of doxycycline for malaria and summarizes the available literature on its safety and tolerability.
• Subjects:
  • Adult
  • Antimalarials
  • Child
  • Doxycycline
  • Drug Interactions
  • Evidence-Based Medicine
  • Female
  • Humans
  • Malaria
  • Pregnancy
• Source:
  Am J Trop Med Hyg. 2011; 84(4):517-531.
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  United States
• Volume:
  84
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/4377/cdc_4377_DS1.pdf
• File Type:
  [PDF - 506.19 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:824adfae1be639e5f61d7ab15c4abb83501fe94364e0969c27daf6d910941ced6c88c972989d8a69323523d5d93302f762c793dca644a29a9b212dd0ac70a57d