Trends in the Treatment of Anemia Using Recombinant Human Erythropoietin in Patients with HIV Infection

Details

• Alternative Title:
  Open AIDS J
• Personal Author:
  Sullivan, Patrick S. ; Hanson, Debra L. ; Richardson, James T. ; Brooks, John T.
• Description:
  Background:
  
  Treating anemia with erythropoietin (EPO) to hemoglobin (Hb) endpoints >11 g/dL may increase risk of serious adverse cardiovascular events.
  
  Methods:
  
  We used medical records data (1996-2003 from the Adolescent Spectrum of HIV Disease Project [ASD] and 1996-2006 from the HIV Outpatient Study [HOPS]) to describe EPO prescription patterns for mildly, moderately, or severely anemic HIV-infected patients. We calculated proportions prescribed EPO and treated to Hb>12 g/dL, and tested for trends over time. We calculated median hemoglobin at first EPO prescription, and described temporal changes using linear regression.
  
  Results:
  
  Among 37,395 patients in ASD and 7,005 patients in HOPS, EPO prescription increased over time for moderately anemic patients; for patients with severe anemia, EPO prescription increased only among ASD patients. Hb at EPO prescription decreased over time in ASD patients (median=8.5 g/dL), but not in HOPS patients (median 9.5 g/dL). Percentage of EPO-treated patients with post-treatment Hb>12 g/dL was 18.3% in ASD and stable, and was 56.7% in HOPS and increased over time (p = 0.03).
  
  Conclusions:
  
  Through 2006, EPO prescription increased over time for patients with moderate or severe anemia. Many patients treated with EPO had post-treatment Hb>12 g/dL. Based on 2011 FDA recommendations, changes in previous prescription practices will be needed.
  
  
• Subjects:
  Anemia Article Erythropoietin. HIV
• Source:
  Open AIDS J. 2011; 5:113-118.
• Document Type:
  Journal Article
• Volume:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:28c386ad8583b40b887c198df88ae4602e9e451c37772122b8bfed318c4f2b2c
• Download URL:
  https://stacks.cdc.gov/view/cdc/4371/cdc_4371_DS1.pdf
• File Type:
  [PDF - 1.45 MB ]