Details:

Alternative Title:
Am J Trop Med Hyg
Publisher's site:
http://dx.doi.org/10.4269/ajtmh.16-0160
Personal Author:
Olliaro, Piero L. ; Barnwell, John W. ; Barry, Alyssa ; Mendis, Kamini ; Mueller, Ivo ; ... More +
Olliaro, Piero L. ; Barnwell, John W. ; Barry, Alyssa ; Mendis, Kamini ; Mueller, Ivo ; Reeder, John C. ; Shanks, G. Dennis ; Snounou, Georges ; Wongsrichanalai, Chansuda ; Less -
Description:
This paper summarizes our current understanding of the biology of Plasmodium vivax, how it differs from Plasmodium falciparum, and how these differences explain the need for P. vivax-tailored interventions. The article further pinpoints knowledge gaps where investments in research are needed to help identify and develop such specific interventions. The principal obstacles to reduce and eventually eliminate P. vivax reside in 1) its higher vectorial capacity compared with P. falciparum due to its ability to develop at lower temperature and over a shorter sporogonic cycle in the vector, allowing transmission in temperate zones and making it less sensitive to vector control measures that are otherwise effective on P. falciparum; 2) the presence of dormant liver forms (hypnozoites), sustaining multiple relapsing episodes from a single infectious bite that cannot be diagnosed and are not susceptible to any available antimalarial except primaquine, with routine deployment restricted by toxicity; 3) low parasite densities, which are difficult to detect with current diagnostics leading to missed diagnoses and delayed treatments (and protracted transmission), coupled with 4) transmission stages (gametocytes) occurring early in acute infections, before infection is diagnosed.
Subject:
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Antimalarials
Articles
Genetic Variation
Global Health
Humans
Life Cycle Stages
Malaria, Vivax
Plasmodium Vivax
Species Specificity

Source:
Am J Trop Med Hyg. 2016 ; 95(6 Suppl):4-14.;
Pubmed ID:
27799636
Pubmed Central ID:
PMC5201222
Document Type:
Journal Article ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:007f4a4c050f99d0e166def15ffe296066c31e13a5a73903e835fa3a49df54b4
File Type:

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