Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0167508
Personal Author:
Ngoi, Carolyne N. ; Price, Matt A. ; Fields, Barry ; Bonventure, Juma ; Ochieng, Caroline ; ... More +
Ngoi, Carolyne N. ; Price, Matt A. ; Fields, Barry ; Bonventure, Juma ; Ochieng, Caroline ; Mwashigadi, Grace ; Hassan, Amin S. ; Thiong’o, Alexander N. ; Micheni, Murugi ; Mugo, Peter ; Graham, Susan ; Sanders, Eduard J. Less -
Description:
Background

Fever is common among patients seeking care in sub-Saharan Africa (sSA), but causes other than malaria are rarely diagnosed. We assessed dengue and chikungunya virus infections among young febrile adults evaluated for acute HIV infection (AHI) and malaria in coastal Kenya.

Methods

We tested plasma samples obtained in a cross-sectional study from febrile adult patients aged 18–35 years evaluated for AHI and malaria at urgent care seeking at seven health facilities in coastal Kenya in 2014–2015. Dengue virus (DENV) and chikungunya virus (CHIKV) were amplified using quantitative real-time reverse-transcription polymerase chain reaction. We conducted logistic regression analyses to determine independent predictors of dengue virus infection.

Results

489 samples that were negative for both AHI and malaria were tested, of which 43 (8.8%, 95% confidence interval [CI]: 6.4–11.7) were positive for DENV infection. No participant was positive for CHIKV infection. DENV infections were associated with clinic visits in the rainy season (adjusted odds ratio (AOR) = 3.0, 95% CI: 1.3–6.5) and evaluation at a private health facility (AOR 5.2, 95% CI: 2.0–13.1) or research health facility (AOR = 25.6, 95% CI: 8.9–73.2) instead of a public health facility.

Conclusion

A high prevalence of DENV infections was found in febrile young adult patients evaluated for AHI. Our data suggests that DENV, along with AHI and malaria, should be considered in the differential diagnosis of the adult patient seeking care for fever in coastal Kenya.


Subject:
[+]
Adolescent
Adult
Chikungunya Fever
Coinfection
Cross-Sectional Studies
Dengue
Female
Fever
HIV Infections
Humans
Malaria
Male
Population Surveillance
Prevalence
Young Adult

Source:
PLoS One. 11(12).
Pubmed ID:
27942016
Pubmed Central ID:
PMC5152832
Document Type:
Journal Article
Place as Subject:
Kenya
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f475c4868a2b61e7241024744b3cceccd03bd066de5a8ff4dce9e85b0c09c196
File Type:

Supporting Files

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