Details:

Alternative Title:
PLoS One
Personal Author:
Carroll, Darin S. ; Emerson, Ginny L. ; Li, Yu ; Sammons, Scott ; Olson, Victoria ; ... More +
Carroll, Darin S. ; Emerson, Ginny L. ; Li, Yu ; Sammons, Scott ; Olson, Victoria ; Frace, Michael ; Nakazawa, Yoshinori ; Czerny, Claus Peter ; Tryland, Morten ; Kolodziejek, Jolanta ; Nowotny, Norbert ; Olsen-Rasmussen, Melissa ; Khristova, Marina ; Govil, Dhwani ; Karem, Kevin ; Damon, Inger K. ; Meyer, Hermann Less -
Description:
Cowpox virus (CPXV) is described as the source of the first vaccine used to prevent the onset and spread of an infectious disease. It is one of the earliest described members of the genus Orthopoxvirus, which includes the viruses that cause smallpox and monkeypox in humans. Both the historic and current literature describe "cowpox" as a disease with a single etiologic agent. Genotypic data presented herein indicate that CPXV is not a single species, but a composite of several (up to 5) species that can infect cows, humans, and other animals. The practice of naming agents after the host in which the resultant disease manifests obfuscates the true taxonomic relationships of "cowpox" isolates. These data support the elevation of as many as four new species within the traditional "cowpox" group and suggest that both wild and modern vaccine strains of Vaccinia virus are most closely related to CPXV of continental Europe rather than the United Kingdom, the homeland of the vaccine.
Subject:
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Animals
Biology
Cluster Analysis
Cowpox Virus
DNA, Viral
Genome, Viral
Humans
Medicine
Molecular Sequence Data
Phylogeny
Research Article
Sequence Analysis, DNA
Species Specificity
Viral Proteins

Source:
PLoS One. 2011; 6(8).
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:1ea1c271df0de61d24d7f7ac9e7b9173b9519736ca11a7bcdc48c11fe82b76f0
File Type:

Supporting Files

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