The bi-directional associations between psychotic experiences and DSM-IV mental disorders

Details

• Alternative Title:
  Am J Psychiatry
• Personal Author:
  McGrath, John J. ; Saha, Sukanta ; Al-Hamzawi, Ali ; Andrade, Laura ; Benjet, Corina ; Bromet, Evelyn J. ; Browne, Mark Oakley ; Caldas de Almeida, Jose M. ; Chiu, Wai Tat ; Demyttenaere, Koen ; Fayyad, John ; Florescu, Silvia ; de Girolamo, Giovanni ; Gureje, Oye ; Haro, Josep Maria ; Have, Margreet ten ; Hu, Chiyi ; Kovess-Masfety, Viviane ; Lim, Carmen C. W. ; Navarro-Mateu, Fernando ; Sampson, Nancy ; Posada-Villa, José ; Kendler, Kenneth ; Kessler, Ronald C.
• Description:
  Objective
  
  While it is now recognized that psychotic experiences (PEs) are associated with an increased risk of later mental disorders, we lack a detailed understanding of the reciprocal time-lagged relationships between first onsets of PEs and mental disorders.
  
  Methods
  
  The WHO World Mental Health (WMH) surveys assessed lifetime prevalence and age-of-onset of PEs and 21 common DSM-IV mental disorders among 31,261 adult respondents from 18 countries.
  
  Results
  
  Temporally primary PEs were significantly associated with subsequent first onset of 8 of the 21 mental disorders (major depressive disorder, bipolar disorder, generalized anxiety disorder, social phobia, post-traumatic stress disorder, adult separation anxiety disorder, bulimia nervosa, alcohol abuse), with ORs (95%CI) ranging from 1.3 (1.2–1.5; major depressive disorder) to 2.0 (1.5–2.6; bipolar disorder). In contrast, 18 of 21 primary mental disorders were significantly associated with subsequent first onset of PEs, with ORs (95% CI) ranging from 1.5 (1.0–2.1; childhood separation anxiety disorder) to 2.8 (1.0–7.8; anorexia nervosa).
  
  Conclusions
  
  While temporally primary PEs are associated with an elevated risk of several subsequent mental disorders, we found that most mental disorder are associated with an elevated risk of subsequent PEs. Further investigation of the underlying factors accounting for these time-order relationships might shed light on the etiology of PEs.
  
  
• Subjects:
  Adolescent Adult Age Of Onset Comorbidity Diagnostic And Statistical Manual Of Mental Disorders Female Health Surveys Humans Male Mental Disorders Prevalence Psychotic Disorders Time Factors Young Adult

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• Source:
  Am J Psychiatry. 173(10):997-1006
• Pubmed ID:
  26988628
• Pubmed Central ID:
  PMC5175400
• Document Type:
  Journal Article
• Funding:
  R01 DA016558/DA/NIDA NIH HHSUnited States/ ; U01 OH010718/OH/NIOSH CDC HHSUnited States/ ; U01 OH010712/OH/NIOSH CDC HHSUnited States/ ; R03 TW006481/TW/FIC NIH HHSUnited States/ ; R01 MH069864/MH/NIMH NIH HHSUnited States/ ; K05 DA015799/DA/NIDA NIH HHSUnited States/ ; U01 MH060220/MH/NIMH NIH HHSUnited States/ ; R01 AG049953/AG/NIA NIH HHSUnited States/ ; R01 MH070884/MH/NIMH NIH HHSUnited States/ ; R13 MH066849/MH/NIMH NIH HHSUnited States/
• Name as Subject:
  World Health Organization
• Volume:
  173
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:78f83e51d32f8834d4e44545c0f156bb06b22c9c0ac3907669efcf8531d8c540
• Download URL:
  https://stacks.cdc.gov/view/cdc/43316/cdc_43316_DS1.pdf
• File Type:
  [PDF - 680.22 KB ]