Objectives-This report describes the development and use of a method for analyzing the literal text from death certificates to enhance national mortality statistics on drug-involved deaths. Drug-involved deaths include drug overdose deaths as well as other deaths where, according to death certificate literal text, drugs were associated with or contributed to the death. Methods-The method uses final National Vital Statistics System-Mortality files linked to electronic files containing literal text information from death certificates. Software programs were designed to search the literal text from three fields of the death certificate (the cause of death from Part I, significant conditions contributing to the death from Part II, and a description of how the injury occurred from Box 43) to identify drug mentions as well as contextual information. The list of drug search terms was developed from existing drug classification systems as well as from manual review of the literal text. Literal text surrounding the identified drug search terms was analyzed to ascertain the context. Drugs mentioned in the death certificate literal text were assumed to be involved in the death unless contextual information suggested otherwise (e.g., "METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION"). The literal text analysis method was assessed by comparing the results from application of the method with results based on ICD-10 codes, and by conducting a manual review of a sample of records. Conclusion: This report details a new method that was developed to extract information from the National Vital Statistics System death certificate literal text to improve national monitoring of drug-involved mortality. The literal text analysis method described in this report leverages existing information on the death certificates for statistical monitoring of drug-involved mortality deaths. Assessments conducted during the methods development process demonstrate that these methods have high accuracy in identifying the drugs mentioned and involved in mortality as well as the corresponding deaths. These methods could be applied to analyze mortality data for causes of death classified to broad ICD categories or for emerging causes of death with no ICD code assigned. Although the methods are limited by the level of drug-specific detail provided in the death certificate literal text, these methods are an enhancement to current ICD–10-coded mortality data. This joint project between the National Center for Health Statistics and the the Office of Surveillance and Epidemiology within the Center for Drug Evaluation and Research of the U.S. Food and Drug Administration (FDA) utilized the information on deaths involving drugs captured in the National Vital Statistics System–Mortality linked with death certificate literal text. Suggested citation: Trinidad JP, Warner M, Bastian BA, et al. Using literal text from the death certificate to enhance mortality statistics: Characterizing drug involvement in deaths. National vital statistics reports; vol 65 no 9. Hyattsville, MD: National Center for Health Statistics. 2016. CS272542

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Stephen B. Thacker CDC Library collection