Immediately Dangerous to Life or Health (IDLH) Value Profile: Diketene [CAS No. 674-82-8]

Details

• Personal Author:
  Dotson, G. Scott ; Maier, Andrew ; Parker, Ann ; Haber, Lynn T.
• Corporate Authors:
  National Institute for Occupational Safety and Health. Education and Information Division
• Description:
  Basis for IDLH value: The IDLH value for diketene is based on the rat BMCL05 of 181 ppm for lethality in a 1-hour exposure [Katz 1987]. The duration adjusted BMCL05 for a 30-minute exposure is 228 ppm. A composite uncertainty factor of 30 was applied to account for extrapolation from a lethal concentration threshold in animals, animal to human differences, human variability, and database uncertainties, resulting in an IDLH value of 7.6 ppm.
  
  Suggested citation: NIOSH [2016]. Immediately dangerous to life or health (IDLH) Value Profile: diketene. By Dotson GS, Maier A, Parker A, Haber L. Cincinnati, OH: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication 2017-108.
  
  
• Subjects:
  Diketene Environmental Exposure Hazardous Substances/adverse Effects Maximum Allowable Concentration Occupational Exposure Threshold Limit Values
• Series:
  NIOSH Numbered Publications
• Subseries:
  Immediately Dangerous to Life or Health (IDLH) Value Profile
• Document Type:
  Text
• Genre:
  Report
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8 numbered pages
• NIOSHTIC Number:
  nn:20049034
• CAS Registry Number:
  Diketene (CAS RN 674-82-8)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e627951371745ce783b24bcec913518fae359e311349631ee9a35f5ffa4aa714e5a50346a5c7d71211fb819c5bc83fc18b45114799498825afcbf6432c065ecb
• Download URL:
  https://stacks.cdc.gov/view/cdc/43246/cdc_43246_DS1.pdf
• File Type:
  [PDF - 364.96 KB ]