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The impact of neighborhoods on cardiovascular risk: the MESA Neighborhood Study
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  • Description:
    Cardiovascular disease (CVD) continues to be the leading cause of death and a major source of health disparities in the Unites States and globally. Efforts to reduce CVD risk and eliminate cardiovascular health disparities have increasingly emphasized the importance of the social determinants of health. Neighborhood environments have emerged as a possible target for prevention and policy efforts. Hence there is a need to better understand the role of neighborhood environments in shaping cardiovascular risk. The MESA (Multi-Ethnic Study of Atherosclerosis) Neighborhood Study provided a unique opportunity to build a comprehensive place-based resource for investigations of associations between specific features of neighborhood physical and social environments and cardiovascular risk factors and outcomes. This review summarizes the approaches used to characterize residential neighborhood environments in the MESA cohort, provides an overview of key findings to date, and discusses challenges and opportunities in neighborhood health effects research. Results to date suggest that neighborhood physical and social environments are related to behavioral and biomedical risk factors for CVD and that cardiovascular prevention efforts may benefit from taking neighborhood context into account.

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  • Funding:
    N01HC95160/HL/NHLBI NIH HHS/United States
    R01 HL071759/HL/NHLBI NIH HHS/United States
    N01HC95163/HL/NHLBI NIH HHS/United States
    UL1 TR001079/TR/NCATS NIH HHS/United States
    N01HC95169/HL/NHLBI NIH HHS/United States
    P60 MD002249/MD/NIMHD NIH HHS/United States
    N01HC95164/HL/NHLBI NIH HHS/United States
    N01HC95162/HL/NHLBI NIH HHS/United States
    N01HC95168/HL/NHLBI NIH HHS/United States
    N01HC95165/HL/NHLBI NIH HHS/United States
    N01HC95159/HL/NHLBI NIH HHS/United States
    CC999999/Intramural CDC HHS/United States
    N01HC95161/HL/NHLBI NIH HHS/United States
    N01HC95167/HL/NHLBI NIH HHS/United States
    UL1 TR000040/TR/NCATS NIH HHS/United States
    N01HC95166/HL/NHLBI NIH HHS/United States
    P2C HD050924/HD/NICHD NIH HHS/United States
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