Human Rhinovirus Infections in Rural Thailand: Epidemiological Evidence for Rhinovirus as Both Pathogen and Bystander

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Fry, Alicia M. ; Lu, Xiaoyan ; Olsen, Sonja J. ; Chittaganpitch, Malinee ; Sawatwong, Pongpun ; Chantra, Somrak ; Baggett, Henry C. ; Erdman, Dean
• Description:
  Background
  
  We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.
  
  Methods
  
  From September 1, 2003–August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.
  
  Results
  
  HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1–4 year: 29%, ≥65 years: 9%; controls: <1 year: 24%, 1–4 year: 14%, ≥65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1–4 years (457), and ≥65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1–4 year (51%) and 5–19 year age groups (54%). Compared to controls, hospitalized adults (≥19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection.
  
  Conclusions
  
  HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.
  
  
• Subjects:
  Adolescent Adult Aged Age Distribution Child Child, Preschool Hospitalization Humans Infant Infant, Newborn Influenza, Human Middle Aged Picornaviridae Infections Rhinovirus Rural Population Seasons Young Adult

  More +
• Source:
  PLoS One. 6(3).
• Document Type:
  Journal Article
• Place as Subject:
  Thailand
• Volume:
  6
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c23cf5b3a95a45f01ba4b7e7daaf72e488d40ef1b3aa6e053e56638ba81b2b4b
• Download URL:
  https://stacks.cdc.gov/view/cdc/4313/cdc_4313_DS1.pdf
• File Type:
  [PDF - 165.45 KB ]