Details:

Alternative Title:
PLoS One
Personal Author:
Fry, Alicia M. ; Lu, Xiaoyan ; Olsen, Sonja J. ; Chittaganpitch, Malinee ; Sawatwong, Pongpun ; ... More +
Fry, Alicia M. ; Lu, Xiaoyan ; Olsen, Sonja J. ; Chittaganpitch, Malinee ; Sawatwong, Pongpun ; Chantra, Somrak ; Baggett, Henry C. ; Erdman, Dean Less -
Description:
Background

We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.

Methods

From September 1, 2003–August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.

Results

HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1–4 year: 29%, ≥65 years: 9%; controls: <1 year: 24%, 1–4 year: 14%, ≥65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1–4 years (457), and ≥65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1–4 year (51%) and 5–19 year age groups (54%). Compared to controls, hospitalized adults (≥19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection.

Conclusions

HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.


Subjects:
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Adolescent Adult Aged Age Distribution Child Child, Preschool Hospitalization Humans Infant Infant, Newborn Influenza, Human Middle Aged Picornaviridae Infections Rhinovirus Rural Population Seasons Young Adult
Source:
PLoS One. 6(3).
Document Type:
Journal Article
Place as Subject:
Thailand
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c23cf5b3a95a45f01ba4b7e7daaf72e488d40ef1b3aa6e053e56638ba81b2b4b
Download URL:
https://stacks.cdc.gov/view/cdc/4313/cdc_4313_DS1.pdf
File Type:

Supporting Files

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