Costs of achieving live birth from assisted reproductive technology: a comparison of sequential single and double embryo transfer approaches
Published Date:Nov 19 2015
Source:Fertil Steril. 105(2):444-450.
Assisted Reproductive Technology (ART)
Double Embryo Transfer (DET)
Health Care Costs
In Vitro Fertilization (IVF)
Sequential Single Embryo Transfer (SET)
Single Embryo Transfer
Pubmed Central ID:PMC5125029
Funding:CC999999/Intramural CDC HHS/United States
To assess treatment and pregnancy/infant-associated medical costs and birth outcomes for assisted reproductive technology (ART) cycles in a subset of patients using elective double embryo (ET) and to project the difference in costs and outcomes had the cycles instead been sequential single ETs (fresh followed by frozen if the fresh ET did not result in live birth).
Retrospective cohort study using 2012 and 2013 data from the National ART Surveillance System.
Infertility treatment centers.
Fresh, autologous double ETs performed in 2012 among ART patients younger than 35 years of age with no prior ART use who cryopreserved at least one embryo.
Sequential single and double ETs.
Main Outcome Measure(s)
Actual live birth rates and estimated ART treatment and pregnancy/infant-associated medical costs for double ET cycles started in 2012 and projected ART treatment and pregnancy/infant-associated medical costs if the double ET cycles had been performed as sequential single ETs.
The estimated total ART treatment and pregnancy/infant-associated medical costs were $580.9 million for 10,001 double ETs started in 2012. If performed as sequential single ETs, estimated costs would have decreased by $195.0 million to $386.0 million, and live birth rates would have increased from 57.7%–68.0%.
Sequential single ETs, when clinically appropriate, can reduce total ART treatment and pregnancy/infant-associated medical costs by reducing multiple births without lowering live birth rates.
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