Birth weight and risk of pediatric Hodgkin lymphoma: findings from a population-based record linkage study in California
Published Date:Nov 01 2016
Source:Eur J Cancer. 69:19-27.
Pubmed Central ID:PMC5125877
HHSN261201000140C/CA/NCI NIH HHS/United States
T32 CA151022/CA/NCI NIH HHS/United States
R01 CA155461/CA/NCI NIH HHS/United States
P01 ES018172/ES/NIEHS NIH HHS/United States
HHSN261201000035I/CA/NCI NIH HHS/United States
R01 CA175737/CA/NCI NIH HHS/United States
HHSN261201000034C/CA/NCI NIH HHS/United States
U58 DP003862/DP/NCCDPHP CDC HHS/United States
To evaluate the relationship between birth weight (along with a variety of pre- and perinatal characteristics) and the risk of pediatric Hodgkin lymphoma (HL) diagnosed at age <20 years.
We linked California statewide birth records from 1978-2009 and cancer diagnosis data from 1988-2011 to conduct a population-based case-control study with 1,216 cases and 4,485 controls (matched on birth month and year, sex, and race/ethnicity). Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) of pediatric HL overall and by age of diagnosis, controlling for other perinatal factors.
Compared to children with a normal birth weight (2,500-3,999 g), those who had a high birth weight (≥ 4000 g) had an increased risk of pediatric HL overall (OR=1.23, 95% CI: 1.02-1.48) after adjusting for birth order, maternal age at the time of delivery, and paternal age at the time of delivery. The magnitude of association appeared larger for subgroups of children whose age of diagnosis was 0-10 years (OR=1.56, 95% CI: 1.04-2.24) or 15-19 years (OR=1.43, 95% CI: 1.11-1.83), while no association was observed in 11-14 year olds. Compared to firstborn children, those who were third or higher in birth order had a reduced risk of pediatric HL overall (OR=0.80, 95% CI: 0.67-0.95), and this association also varied by age of diagnosis.
In this study with the largest number of pediatric HL cases, high birth weight was associated with an increased disease risk for most but not all ages of diagnosis. The different findings by age of diagnosis regarding both birth weight and birth order underscore the importance to stratify pediatric HL by age at diagnosis in future etiological investigations.
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