An Outbreak of Dengue Fever in St. Croix (US Virgin Islands), 2005

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Mohammed, Hamish ; Ramos, Mary ; Armstrong, Julie ; Muñoz-Jordán, Jorge ; Arnold-Lewis, Kathleen O. ; Ayala, Aurimar ; Clark, Gary G. ; Tull, Eugene S. ; Beatty, Mark E.
• Description:
  Background
  
  Periodic outbreaks of dengue fever occur in the United States Virgin Islands. In June 2005, an outbreak of dengue virus (DENV) serotype-2 with cases of dengue hemorrhagic fever (DHF) was detected in St. Croix, US Virgin Islands. The objective of this report is to describe this outbreak of DENV-2 and the findings of a case-control study examining risk factors for DHF.
  
  Methodology/Principal Findings
  
  This is the largest dengue outbreak ever recorded in St. Croix, with 331 suspected dengue cases reported island-wide during 2005 (62.2 cases/10,000 population); 54% were hospitalized, 21% had at least one hemorrhagic manifestation, 28% had thrombocytopenia, 5% had DHF and 1 patient died. Eighty-nine laboratory-positive hospitalized patients were identified. Of these, there were 15 (17%) who met the WHO criteria for DHF (cases) and 74 (83%) who did not (controls). The only variable significantly associated with DHF on bivariate or multivariable analysis was age, with an adjusted odds ratio (95% confidence interval) of 1.033 (1.003,1.064).
  
  Conclusions/Significance
  
  During this outbreak of DENV-2, a high proportion of cases developed DHF and increasing age was significantly associated with DHF.
  
  
• Subjects:
  Case-Control Studies Dengue Disease Outbreaks Humans Research Article Reverse Transcriptase Polymerase Chain Reaction
• Source:
  PLoS One. 5(10).
• Document Type:
  Journal Article
• Place as Subject:
  United States Virgin Islands
• Volume:
  5
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ee8ea1021123ce2120ab027fbc167f9266715df0d54c1c8135732e86c1951b4a7c05dda1707827390dcbdd4eada26003746a9f73418b04230f07a1c5e09580db
• Download URL:
  https://stacks.cdc.gov/view/cdc/4294/cdc_4294_DS1.pdf
• File Type:
  [PDF - 164.10 KB ]