Details:

Alternative Title:
Diagn Microbiol Infect Dis
Personal Author:
Wormser, Gary P. ; Sudhindra, Praveen ; Lopez, Eliana ; Patel, Lisa ; Rezai, Sara ; ... More +
Wormser, Gary P. ; Sudhindra, Praveen ; Lopez, Eliana ; Patel, Lisa ; Rezai, Sara ; Brumbaugh, Aaron D. ; McKenna, Donna ; Scavarda, Carol ; Shapiro, Eugene D. ; Karmen, Carol L. ; Visintainer, Paul Less -
Description:
Background

Fatigue is a common symptom in patients with Lyme disease.

Objective

The purpose of this study was to characterize fatigue in untreated adult patients presenting with erythema migrans. Selected variables were assessed to determine if any correlated with the presence or severity of fatigue.

Methods

Fatigue was assessed on the day of the evaluation by a visual analogue scale (VAS), over the past 14 days by the 11-item fatigue severity scale (FSS-11) and over the past 28 days based on a question from the 36-item Short Form General Health Survey version 2.

Results

51 patients with erythema migrans whose mean age was 49.8 years, and 33 (64.7%) of whom were male, were evaluated in this study. The three measures of fatigue were positively correlated with one another (p ≤ 0.01). 26 (51%) had fatigue based on a VAS score above 0. 10 (19.6%) had severe fatigue based on an FSS-11 score of ≥ 4. The strongest correlate for higher fatigue scores was having a greater number of symptoms in addition to fatigue.

Conclusion

Based on the FSS-11 assessment tool, approximately 20% of early Lyme patients have severe fatigue. Having a high total number of symptoms was associated with both the presence and severity of fatigue. Since prior studies have demonstrated the presence of elevated levels of pro-inflammatory cytokines and other molecules in the serum of highly symptomatic patients with erythema migrans, the symptom of fatigue in early Lyme disease may be a component of what has been referred to as the acute sickness response.


Subject:
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Acute Sickness Response
Adult
Aged
Aged, 80 And Over
Article
Borrelia Burgdorferi
Fatigue
Female
Humans
Lyme Disease
Male
Middle Aged
Prospective Studies
Surveys And Questionnaires
Young Adult
Lyme Disease

Source:
Diagn Microbiol Infect Dis. 86(3):322-326
Pubmed ID:
27553702
Pubmed Central ID:
PMC5061607
Document Type:
Journal Article
Funding:
KL2 TR000140/TR/NCATS NIH HHS/United States ; R01 CK000152/CK/NCEZID CDC HHS/United States ; UL1 TR000142/TR/NCATS NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States
KL2 TR000140/TR/NCATS NIH HHS/United States ; R01 CK000152/CK/NCEZID CDC HHS/United States ; UL1 TR000142/TR/NCATS NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f076abcdbd654a23560ed1d3919d904e2dc6cf654c8dc29491de47bc301e933e
File Type:

Supporting Files

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  	nihms-806239-f0001.jpg	jpeg
  	nihms-806239.nxml	xml

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