Estimation of the Human Extrathoracic Deposition Fraction of Inhaled Particles Using a Polyurethane Foam Collection Substrate in an IOM Sampler

Details

• Alternative Title:
  Int J Environ Res Public Health
• Personal Author:
  Sleeth, Darrah K. ; Balthaser, Susan A. ; Collingwood, Scott ; Larson, Rodney R.
• Description:
  Extrathoracic deposition of inhaled particles (i.e., in the head and throat) is an important exposure route for many hazardous materials. Current best practices for exposure assessment of aerosols in the workplace involve particle size selective sampling methods based on particle penetration into the human respiratory tract (i.e., inhalable or respirable sampling). However, the International Organization for Standardization (ISO) has recently adopted particle deposition sampling conventions (ISO 13138), including conventions for extrathoracic (ET) deposition into the anterior nasal passage (ET₁) and the posterior nasal and oral passages (ET₂). For this study, polyurethane foam was used as a collection substrate inside an inhalable aerosol sampler to provide an estimate of extrathoracic particle deposition. Aerosols of fused aluminum oxide (five sizes, 4.9 µm-44.3 µm) were used as a test dust in a low speed (0.2 m/s) wind tunnel. Samplers were placed on a rotating mannequin inside the wind tunnel to simulate orientation-averaged personal sampling. Collection efficiency data for the foam insert matched well to the extrathoracic deposition convention for the particle sizes tested. The concept of using a foam insert to match a particle deposition sampling convention was explored in this study and shows promise for future use as a sampling device.
• Subjects:
  Aerosols Air Pollutants, Occupational Article Environmental Monitoring Humans Inhalation Exposure Models, Theoretical Mouth Nasal Cavity Occupational Exposure Particle Size Polyurethanes Specimen Handling

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• Source:
  Int J Environ Res Public Health. 2016; 13(3).
• Pubmed ID:
  26959046
• Pubmed Central ID:
  PMC4808955
• Document Type:
  Journal Article
• Funding:
  K01 OH010188/OH/NIOSH CDC HHS/United States ; K01/OH010188/OH/NIOSH CDC HHS/United States
• Name as Subject:
  Institute of Medicine (U.S.)
• Place as Subject:
  United States
• Volume:
  13
• Issue:
  3
• NIOSHTIC Number:
  nn:20048941
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8119f48a760695b4d8bbc1df2c1347ffa9ee31bf9b98ecdcbe1d3a79057f8d2554c1fa5aca862d82098fd2f1042caad85569cce19c6442f4ac97c69bce755a40
• Download URL:
  https://stacks.cdc.gov/view/cdc/42898/cdc_42898_DS1.pdf
• File Type:
  [PDF - 1.88 MB ]