Details:

Alternative Title:
PLoS One
Personal Author:
Hladik, Wolfgang ; Stover, John ; Esiru, Godfrey ; Harper, Malayah ; Tappero, Jordan
Hladik, Wolfgang ; Stover, John ; Esiru, Godfrey ; Harper, Malayah ; Tappero, Jordan Less -
Description:
Background

Uganda has one of the highest total fertility rates (TFR) worldwide. We compared the effects of antiretroviral (ARV) prophylaxis for the prevention of mother-to-child HIV transmission (PMTCT) to that of existing family planning (FP) use and estimated the burden of pediatric HIV disease due to unwanted fertility.

Methodology/Principal Findings

Using the demographic software Spectrum, a baseline mathematical projection to estimate the current pediatric HIV burden in Uganda was compared to three hypothetical projections: 1) without ARV-PMTCT (to estimate the effect of ARV-PMTCT), 2) without contraception (effect of existing FP use), 3) without unwanted fertility (effect of unmet FP needs). Key input parameters included HIV prevalence, ARV-PMTCT uptake, MTCT probabilities, and TFR. We estimate that in 2007, an estimated 25,000 vertical infections and 17,000 pediatric AIDS deaths occurred (baseline projection). Existing ARV-PMTCT likely averted 8.1% of infections and 8.5% of deaths. FP use likely averted 19.7% of infections and 13.1% of deaths. Unwanted fertility accounted for 21.3% of infections and 13.4% of deaths. During 2008–2012, an estimated 131,000 vertical infections and 71,000 pediatric AIDS deaths will occur. The projected scale up of ARV-PMTCT (from 39%–57%) may avert 18.1% of infections and 24.5% of deaths. Projected FP use may avert 21.6% of infections and 18.5% of deaths. Unwanted fertility will account for 24.5% of infections and 19.8% of deaths.

Conclusions

Existing FP use contributes as much or more than ARV-PMTCT in mitigating pediatric HIV in Uganda. Expanding FP services can substantially contribute towards PMTCT.


Subjects:
[+]
Acquired Immunodeficiency Syndrome Adolescent Adult Anti-Retroviral Agents Female HIV Infections Humans Infant, Newborn Infectious Disease Transmission, Vertical Male Middle Aged Pregnancy Pregnancy Complications, Infectious Prevalence Software
Source:
PLoS One. 4(11).
Pubmed ID:
19888347
Pubmed Central ID:
PMC2766039
Document Type:
Journal Article
Place as Subject:
Uganda
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:d219243178b45a41679a3f4fc197a0fa23f06a3ac2e7d4697965f19cb133c368
Download URL:
https://stacks.cdc.gov/view/cdc/4275/cdc_4275_DS1.pdf
File Type:

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