Factors associated with recurrent tuberculosis more than 12 months after treatment completion

Details

• Alternative Title:
  Int J Tuberc Lung Dis
• Personal Author:
  Kim, Lindsay ; Moonan, Patrick K. ; Heilig, Charles M. ; Yelk Woodruff, Rachel S. ; Kammerer, J. Steve ; Haddad, Maryam B.
• Description:
  Setting
  
  Even in persons with complete treatment of their first tuberculosis (TB) episode, patients with a TB history are at higher risk for having TB.
  
  Objective
  
  Describe factors from the initial TB episode associated with recurrent TB among patients who completed treatment and remained free of TB for at least 12 months.
  
  Design
  
  US TB cases, stratified by birth origin, during 1993–2006 were examined. Cox proportional hazards regression was employed to assess the association of factors during the initial episode with recurrence at least 12 months after treatment completion.
  
  Results
  
  Among 632 US-born patients, TB recurrence was associated with age 25–44 (adjusted hazard ratio [aHR] 1.77, 99% confidence interval [CI] 1.02–3.09, attributable fraction [AF] 1%–34%), substance use (aHR 1.57, 99%CI 1.23–2.02, AF 8%–22%), and treatment supervised by health departments (aHR 1.42, 99%CI 1.03–1.97, AF 2%–28%). Among 211 foreign-born patients, recurrence was associated with HIV infection (aHR 2.24, 99%CI 1.27–3.98, AF 2%–9%) and smear-positive TB (aHR 1.56, 99%CI 1.06–2.30, AF 3%–33%).
  
  Conclusion
  
  Factors associated with recurrence differed by birth origin and might be useful for anticipating greater risk for recurrent TB among certain patients with a TB history.
  
  
• Subjects:
  Adolescent Adult Aged Antitubercular Agents Child Child, Preschool Cohort Studies Female Humans Infant Infant, Newborn Male Middle Aged Proportional Hazards Models Recurrence Retrospective Studies Risk Factors Treatment Outcome Tuberculosis, Pulmonary Young Adult

  More +
• Source:
  Int J Tuberc Lung Dis. 20(1):49-56
• Pubmed ID:
  26688528
• Pubmed Central ID:
  PMC5082738
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  20
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7f64e6c46b20aa2a56efef59fe762c22b60daf620ec4892baa7d13db5a92879c
• Download URL:
  https://stacks.cdc.gov/view/cdc/42299/cdc_42299_DS1.pdf
• File Type:
  [PDF - 292.56 KB ]