Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects

Details

• Alternative Title:
  J Water Health
• Personal Author:
  Weyer, Peter J. ; Brender, Jean D. ; Romitti, Paul A. ; Kantamneni, Jiji R. ; Crawford, David ; Sharkey, Joseph R. ; Shinde, Mayura ; Horel, Scott A. ; Vuong, Ann M. ; Langlois, Peter H.
• Description:
  Previous epidemiologic studies of maternal exposure to drinking water nitrate did not account for bottled water consumption. The objective of this National Birth Defects Prevention Study (NBDPS) (USA) analysis was to assess the impact of bottled water use on the relation between maternal exposure to drinking water nitrate and selected birth defects in infants born during 1997-2005. Prenatal residences of 1,410 mothers reporting exclusive bottled water use were geocoded and mapped; 326 bottled water samples were collected and analyzed using Environmental Protection Agency Method 300.0. Median bottled water nitrate concentrations were assigned by community; mothers' overall intake of nitrate in mg/day from drinking water was calculated. Odds ratios for neural tube defects, limb deficiencies, oral cleft defects, and heart defects were estimated using mixed-effects models for logistic regression. Odds ratios (95% CIs) for the highest exposure group in offspring of mothers reporting exclusive use of bottled water were: neural tube defects [1.42 (0.51, 3.99)], limb deficiencies [1.86 (0.51, 6.80)], oral clefts [1.43 (0.61, 3.31)], and heart defects [2.13, (0.87, 5.17)]. Bottled water nitrate had no appreciable impact on risk for birth defects in the NBDPS.
• Subjects:
  Article Birth Defects Bottled Water Case-Control Studies Congenital Abnormalities Drinking Water Female Humans Infant, Newborn Logistic Models Maternal Exposure Nitrate Nitrates Odds Ratio Pregnancy Prenatal Exposure Delayed Effects United States

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• Source:
  J Water Health. 12(4):755-762.
• Pubmed ID:
  25473985
• Pubmed Central ID:
  PMC5072402
• Document Type:
  Journal Article
• Funding:
  3R01ES015634-03S1/ES/NIEHS NIH HHS/United States ; 5R01ES015634/ES/NIEHS NIH HHS/United States ; U01 DD000494/DD/NCBDD CDC HHS/United States ; U01DD00494/DD/NCBDD CDC HHS/United States ; R01 ES015634/ES/NIEHS NIH HHS/United States
• Volume:
  12
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ad899cbf99ddcca89cbf9f267befc610aa197f27fec60bbe41bc5a230547db32
• Download URL:
  https://stacks.cdc.gov/view/cdc/42211/cdc_42211_DS1.pdf
• File Type:
  [PDF - 83.01 KB ]