Details:

Alternative Title:
Am J Ind Med
Personal Author:
Charles, Luenda E. ; Zhao, Songzhu ; Fekedulegn, Desta ; Violanti, John M. ; Andrew, Michael E. ; ... More +
Charles, Luenda E. ; Zhao, Songzhu ; Fekedulegn, Desta ; Violanti, John M. ; Andrew, Michael E. ; Burchfiel, Cecil M. Less -
Description:
Background

Our objective was to assess the influence of shiftwork on change in endothelial function.

Methods

This longitudinal study was conducted in 188 police officers (78.2% men). Shiftwork status (day, afternoon, night) was assessed objectively using daily Buffalo, NY payroll work history records. Brachial artery flow-mediated dilation (FMD) was assessed using ultrasound. Mean change in FMD% between 2004–2009 and 2010–2015 was compared across shiftwork using analysis of variance/covariance.

Results

Overall, mean FMD% decreased from 5.74 ± 2.83 to 3.88 ± 2.11 over an average of 7 years among all officers; P < 0.0001. Effect modification by gender was significant. Among men (but not women), those who worked day shifts had a smaller mean (±SE) decrease in FMD% (−0.89 ± 0.35) compared with those who worked the afternoon (−2.69 ± 0.39; P = 0.001) or night shifts (−2.31 ± 0.45; P = 0.020) after risk factor adjustment.

Conclusions

Larger declines in endothelial function were observed among men who worked afternoon or night shifts. Further investigation is warranted. Am. J. Ind. Med. Published 2016. This article is a U.S. Government work and is in the public domain in the USA


Subjects:
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Adult Aged Analysis Of Variance Article Blood Flow Velocity Brachial Artery Brachial Artery Reactivity Endothelial Function Endothelium, Vascular Female Flow-mediated Dilation Humans Law Enforcement Officers Longitudinal Studies Male Middle Aged Police Police Officers Regional Blood Flow Sex Factors Shiftwork Ultrasonography Vasodilation Work Schedule Tolerance
Source:
Am J Ind Med. 59(11):1001-1008
Pubmed ID:
27245641
Pubmed Central ID:
PMC5069123
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; R01 OH009640/OH/NIOSH CDC HHS/United States ; R01 OH010807/OH/NIOSH CDC HHS/United States
CC999999/Intramural CDC HHS/United States ; R01 OH009640/OH/NIOSH CDC HHS/United States ; R01 OH010807/OH/NIOSH CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b8de08ea778010a2caf939996d673067414355ca984c0571e291f4df3dcb4bd0
Download URL:
https://stacks.cdc.gov/view/cdc/42203/cdc_42203_DS1.pdf
File Type:

Supporting Files

• nihms-792217.nxml

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