Welcome to CDC stacks | Nested Case-Control Study: Hepatocellular Carcinoma Risk After Hepatitis B Surface Antigen Seroclearance - 42180 | Arctic Investigations Program | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
Clear All Simple Search
Advanced Search
Nested Case-Control Study: Hepatocellular Carcinoma Risk After Hepatitis B Surface Antigen Seroclearance
Filetype[PDF-374.54 KB]

  • Pubmed ID:
  • Pubmed Central ID:
  • Description:

    Hepatocellular carcinoma (HCC) risk after resolving chronic hepatitis B virus (HBV) infection is unclear.


    To compare HCC risk between Alaska Native (AN) patients with and without hepatitis B surface antigen (HBsAg) seroclearance.


    We selected persons with (case-patients) and without (control-patients) HBsAg seroclearance from a cohort of 1,346 chronically HBV-infected AN patients followed during 1982–2013. We attempted to match 2 control-patients/case-patient on sex, HBV genotype, and age. Person-years of follow-up for case-patients began on the date of HBsAg resolution and for control-patients began on the date equivalent to the cohort entry date plus the years of HBsAg duration for their corresponding case-patient. We compared HCC risk using a Cox proportional hazards model.


    The 238 case-patients (4 with HCC) and 435 control-patients (9 with HCC) were similar in age (p-value [p]: 0.30), sex (p: 0.53) and HBV genotype (p: 0.99). Case-patients had longer person-years of follow-up than control patients (11.7 versus 10.1 years; p: 0.04). The HCC rate/100,000 persons was similar between case- (132) and control-patients (178; p: 0.65). The adjusted hazard ratio comparing case- and control-patients was similar for HCC (0.7; 95% confidence interval [CI]: 0.2–2.4), increased for each 1-year increment for age (1.1; CI: 1.0–1.1; p <0.01), and was greater if the initial HBeAg was positive (3.5; CI: 1.1–11.0; p: 0.03).


    HBsAg seroclearance was not associated with reduced HCC risk; the HCC risk estimates are limited by wide CIs. Persons meeting HCC surveillance indications prior to HBsAg seroclearance could benefit from continued surveillance after seroclearance.

  • Document Type:
  • Funding:
    CC999999/Intramural CDC HHS/United States
    U01 PS004113/PS/NCHHSTP CDC HHS/United States
No Related Documents.
You May Also Like: