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Clinician Perspectives on Using Pharmacogenomics in Clinical Practice
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  • Pubmed ID:
  • Pubmed Central ID:
  • Description:

    To describe the knowledge and attitudes of clinicians participating in a large pharmacogenomics implementation program.

    Materials & methods

    Semi-structured interviews with 15 physicians and nurse practitioners were conducted.


    Three categories of themes were identified: preparation and knowledge, pharmacogenomics usage in practice, and future management of genomic variants. Providers expressed an inability to keep up with the rapid pace of evidence generation and indicated strong support for clinical decision support to assist with genotype-tailored therapies. Concerns raised by clinicians included effectively communicating results, long-term responsibility for actionable results and hand-offs with providers outside the implementation program.


    Clinicians identified their own knowledge deficits, workflow integration, and longitudinal responsibility as challenges to successful usage of pharmacogenomics in clinical practice.

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  • Funding:
    U01 HL105198/HL/NHLBI NIH HHS/United States
    U01 HG007253/HG/NHGRI NIH HHS/United States
    UL1 TR000445/TR/NCATS NIH HHS/United States
    U01 HL122904/HL/NHLBI NIH HHS/United States
    U19 HL065962/HL/NHLBI NIH HHS/United States
    U47 CI000824/CI/NCPDCID CDC HHS/United States
    U01 HG006378/HG/NHGRI NIH HHS/United States
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