Clinician Perspectives on Using Pharmacogenomics in Clinical Practice
Source:Per Med. 12(4):339-347.
Pubmed Central ID:PMC4664195
Funding:U01 HL105198/HL/NHLBI NIH HHS/United States
U01 HG007253/HG/NHGRI NIH HHS/United States
UL1 TR000445/TR/NCATS NIH HHS/United States
U01 HL122904/HL/NHLBI NIH HHS/United States
U19 HL065962/HL/NHLBI NIH HHS/United States
U47 CI000824/CI/NCPDCID CDC HHS/United States
U01 HG006378/HG/NHGRI NIH HHS/United States
To describe the knowledge and attitudes of clinicians participating in a large pharmacogenomics implementation program.
Materials & methods
Semi-structured interviews with 15 physicians and nurse practitioners were conducted.
Three categories of themes were identified: preparation and knowledge, pharmacogenomics usage in practice, and future management of genomic variants. Providers expressed an inability to keep up with the rapid pace of evidence generation and indicated strong support for clinical decision support to assist with genotype-tailored therapies. Concerns raised by clinicians included effectively communicating results, long-term responsibility for actionable results and hand-offs with providers outside the implementation program.
Clinicians identified their own knowledge deficits, workflow integration, and longitudinal responsibility as challenges to successful usage of pharmacogenomics in clinical practice.
You May Also Like: