Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts

Details

• Alternative Title:
  Am J Prev Med
• Personal Author:
  Gu, Fangyi ; Han, Jiali ; Laden, Francine ; Pan, An ; Caporaso, Neil E. ; Stampfer, Meir J. ; Kawachi, Ichiro ; Rexrode, Kathryn M. ; Willett, Walter C. ; Hankinson, Susan E. ; Speizer, Frank ; Schernhammer, Eva S.
• Description:
  Background
  
  Rotating night shift work imposes circadian strain and is linked to the risk of several chronic diseases.
  
  Purpose
  
  To examine associations between rotating night shift work and all-cause, cardiovascular disease (CVD), and cancer mortality in a prospective cohort study of 74,862 registered U.S. nurses from the Nurses’ Health Study.
  
  Methods
  
  Lifetime rotating night shift work (defined as ≥3 nights/month) information was collected in 1988. During 22 years (1988–2010) of follow-up, 14,181 deaths were documented, including 3,062 CVD and 5,413 cancer deaths. Cox proportional hazards models (2013) estimated multivariable-adjusted hazard ratios (HRs) and 95% CIs.
  
  Results
  
  All-cause and CVD mortality were significantly increased among women with ≥5 years of rotating night shift work, compared to women who never worked night shifts. Specifically, for women with 6–14 and ≥15 years of rotating night shift work, the HRs were 1.11 (95% CI=1.06, 1.17) and 1.11 (95% CI=1.05, 1.18) for all-cause mortality and 1.19 (95% CI=1.07, 1.33) and 1.23 (95% CI=1.09, 1.38) for CVD mortality. There was no association between rotating night shift work and all-cancer mortality (HR≥15years=1.08, 95% CI=0.89, 1.19) or any other cancer, with the exception of lung cancer (HR≥15years=1.25, 95% CI=1.04, 1.51).
  
  Conclusions
  
  Women working rotating night shifts for ≥5 five years have a modest increase in all-cause and CVD mortality; those working ≥15 years of rotating night shift work have a modest increase in lung cancer mortality. These results add to prior evidence of a potentially detrimental effect of rotating night shift work on health and longevity.
  
  
• Subjects:
  Adult Age Factors Cardiovascular Diseases Female Health Behavior Humans Life Style Middle Aged Neoplasms Nurses Proportional Hazards Models Prospective Studies Risk Factors Socioeconomic Factors Time Factors United States Women's Health Work Schedule Tolerance

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• Source:
  Am J Prev Med. 2014; 48(3):241-252
• Pubmed ID:
  25576495
• Pubmed Central ID:
  PMC4339532
• Document Type:
  Journal Article
• Funding:
  R01 CA050385/CA/NCI NIH HHSUnited States/ ; R01 CA114534/CA/NCI NIH HHSUnited States/ ; HL034594/HL/NHLBI NIH HHSUnited States/ ; ImNIH/Intramural NIH HHSUnited States/ ; CA50385/CA/NCI NIH HHSUnited States/ ; R01 OH009803/OH/NIOSH CDC HHSUnited States/ ; P01 CA087969/CA/NCI NIH HHSUnited States/ ; CA87969/CA/NCI NIH HHSUnited States/ ; R01OH009803/ACL/ACL HHSUnited States/ ; R01 HL034594/HL/NHLBI NIH HHSUnited States/ ; UM1 CA186107/CA/NCI NIH HHSUnited States/
• Volume:
  48
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a853279c15edd9c63be3494aca29d9e04881526f4d3e0c859aa5ef13f3122bf0
• Download URL:
  https://stacks.cdc.gov/view/cdc/42025/cdc_42025_DS1.pdf
• File Type:
  [PDF - 366.12 KB ]