Change in adiposity minimally affects the lipid profile in youth with recent onset type 1 diabetes

Shah, Amy S; Dolan, Lawrence M; Dabelea, Dana; Stafford, Jeanette M; D’Agostino, Ralph B; Mayer-Davis, Elizabeth J; Marcovina, Santica; Imperatore, Giuseppina; Wadwa, R Paul; Daniels, Stephen R; Reynolds, Kristi; Hamman, Richard F.; Bowlby, Deborah A; Maahs, David M

doi:10.1111/pedi.12162

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Change in adiposity minimally affects the lipid profile in youth with recent onset type 1 diabetes

Published Date:

Aug 07 2014

Publisher's site:

http://dx.doi.org/10.1111/pedi.12162 New Site Icon

Source:

Pediatr Diabetes. 16(4):280-286.

[PDF-173.17 KB]

Details:

Personal Authors:

Shah, Amy S ; Dolan, Lawrence M ; Dabelea, Dana ; Stafford, Jeanette M ; D’Agostino, Ralph B ; ... More ▼

Corporate Authors:

for the SEARCH for Diabetes in Youth study

Keywords:

[+]

Pubmed ID:

25099744

Pubmed Central ID:

PMC4320680

Description:

Objective

Dyslipidemia contributes to the increased risk of cardiovascular disease in persons with type 1 diabetes (T1D). Weight control is commonly recommended as a treatment for dyslipidemia. However, the extent to which decreases in weight affect the lipid profile in youth with T1D is not known. Therefore, we tested the hypothesis that decreases in BMI-z score (BMIz) were associated with concomitant changes in the lipid profile in youth with T1D.

Study Design

We studied 1142 youth with incident T1D who had at least 2 fasting lipid measurements over 2 years (initial visit mean: age=10.8±3.9 years, BMIz=0.55±0.97, T1D duration=10.7±7.6 months; 47.5% female, 77.9% non-Hispanic white) in the SEARCH for Diabetes in Youth study. Longitudinal mixed models were used to examine the relationships between changes in BMIz and changes in total, LDL-C, HDL-C, non-HDL cholesterol, and log triglycerides adjusted for initial age, sex, race/ethnicity, clinical site, season of study visit, T1D duration and glycated hemoglobin (HbA1c).

Results

We found that over 2 years all lipid levels, except LDL-C, increased significantly (p<0.05). Decreases in BMIz were associated with favorable changes in HDL-C and TG only and the magnitude of these changes depended on the initial BMIz value (interaction p<0.05), so that greater improvements are seen in those with higher BMIz.

Conclusions

Our data suggest that weight loss may be an effective, but limited, therapeutic approach for dyslipidemia in youth with T1D.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Supporting Files:

nihms598245.nxml

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