Change in adiposity minimally affects the lipid profile in youth with recent onset type 1 diabetes
Published Date:Aug 07 2014
Source:Pediatr Diabetes. 16(4):280-286.
Corporate Authors:for the SEARCH for Diabetes in Youth study
Pubmed Central ID:PMC4320680
Funding:P30 DK057516/DK/NIDDK NIH HHS/United States
M01RR00037/RR/NCRR NIH HHS/United States
U01 DP000247/DP/NCCDPHP CDC HHS/United States
U18 DP002710/DP/NCCDPHP CDC HHS/United States
K23 HL118132/HL/NHLBI NIH HHS/United States
M01 RR000069/RR/NCRR NIH HHS/United States
UL1 TR000154/TR/NCATS NIH HHS/United States
U18 DP002714/DP/NCCDPHP CDC HHS/United States
U01 DP000248/DP/NCCDPHP CDC HHS/United States
M01 RR000037/RR/NCRR NIH HHS/United States
U01 DP000244/DP/NCCDPHP CDC HHS/United States
P30 DK57516/DK/NIDDK NIH HHS/United States
1UL1RR026314-01/RR/NCRR NIH HHS/United States
UL1 RR029882/RR/NCRR NIH HHS/United States
M01 RR00069/RR/NCRR NIH HHS/United States
U18 DP002709/DP/NCCDPHP CDC HHS/United States
UL1 TR001082/TR/NCATS NIH HHS/United States
UL1 TR000077/TR/NCATS NIH HHS/United States
UL1 TR000423/TR/NCATS NIH HHS/United States
U01 DP000250/DP/NCCDPHP CDC HHS/United States
U01 DP000246/DP/NCCDPHP CDC HHS/United States
U01 DP000254/DP/NCCDPHP CDC HHS/United States
UL1 RR026314/RR/NCRR NIH HHS/United States
U18 DP002708/DP/NCCDPHP CDC HHS/United States
UL1RR029882/RR/NCRR NIH HHS/United States
HIR 10-001/HX/HSRD VA/United States
Dyslipidemia contributes to the increased risk of cardiovascular disease in persons with type 1 diabetes (T1D). Weight control is commonly recommended as a treatment for dyslipidemia. However, the extent to which decreases in weight affect the lipid profile in youth with T1D is not known. Therefore, we tested the hypothesis that decreases in BMI-z score (BMIz) were associated with concomitant changes in the lipid profile in youth with T1D.
We studied 1142 youth with incident T1D who had at least 2 fasting lipid measurements over 2 years (initial visit mean: age=10.8±3.9 years, BMIz=0.55±0.97, T1D duration=10.7±7.6 months; 47.5% female, 77.9% non-Hispanic white) in the SEARCH for Diabetes in Youth study. Longitudinal mixed models were used to examine the relationships between changes in BMIz and changes in total, LDL-C, HDL-C, non-HDL cholesterol, and log triglycerides adjusted for initial age, sex, race/ethnicity, clinical site, season of study visit, T1D duration and glycated hemoglobin (HbA1c).
We found that over 2 years all lipid levels, except LDL-C, increased significantly (p<0.05). Decreases in BMIz were associated with favorable changes in HDL-C and TG only and the magnitude of these changes depended on the initial BMIz value (interaction p<0.05), so that greater improvements are seen in those with higher BMIz.
Our data suggest that weight loss may be an effective, but limited, therapeutic approach for dyslipidemia in youth with T1D.
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