Overall and abdominal adiposity and premenopausal breast cancer risk among Hispanic women: The Breast Cancer Health Disparities Study
Published Date:Oct 28 2014
Source:Cancer Epidemiol Biomarkers Prev. 24(1):138-147.
Body Mass Index
Estrogen Receptor Status
Progesterone Receptor Status
Pubmed Central ID:PMC4294975
Funding:CA77305/CA/NCI NIH HHS/United States
R01 CA078552/CA/NCI NIH HHS/United States
HHSN261201000036C/CA/NCI NIH HHS/United States
R01 CA078762/CA/NCI NIH HHS/United States
U58 DP000807/DP/NCCDPHP CDC HHS/United States
R01 CA078802/CA/NCI NIH HHS/United States
R01 CA078682/CA/NCI NIH HHS/United States
R01 CA140002/CA/NCI NIH HHS/United States
R01 CA063446/CA/NCI NIH HHS/United States
CA63446/CA/NCI NIH HHS/United States
Few studies in Hispanic women have examined the relation between adult body size and risk of premenopausal breast cancer defined by hormone receptor status.
The Breast Cancer Health Disparities Study pooled interview and anthropometric data from two large U.S. population-based case-control studies. We examined associations of overall and abdominal adiposity with risk of estrogen receptor and progesterone receptor positive (ER+PR+) and negative (ER−PR−) breast cancer in Hispanic and non-Hispanic White (NHW) women, calculating odds ratios (OR) and 95% confidence intervals (CI).
Among Hispanics, young-adult and current body mass index (BMI) were inversely associated with both ER+PR+ and ER−PR− breast cancer. For ER+PR+ disease, risk was substantially reduced among those with elevated BMI throughout adulthood (OR=0.35, 95% CI=0.19-0.62). Height and height-to-waist ratio were positively associated with ER−PR− breast cancer. After adjustment for current BMI, two-fold increased risks were seen for large waist and hip circumferences, regardless of tumor receptor status. Genetic ancestry appeared to modify some of the associations with overall and abdominal adiposity. Among NHWs, findings for overall adiposity were similar to those for Hispanics, but there was no evidence of associations with abdominal adiposity.
Our findings for Hispanic women were generally similar to those reported for NHW women in other studies, with inverse associations for overall adiposity and positive associations for abdominal adiposity.
Abdominal obesity in young adulthood is an important risk factor for premenopausal breast cancer among Hispanic women.
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