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Overall and abdominal adiposity and premenopausal breast cancer risk among Hispanic women: The Breast Cancer Health Disparities Study
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Oct 28 2014
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Source: Cancer Epidemiol Biomarkers Prev. 24(1):138-147.
[PDF-843.22 KB]
Details:
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Alternative Title:Cancer Epidemiol Biomarkers Prev
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Personal Author:
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Description:Background
Few studies in Hispanic women have examined the relation between adult body size and risk of premenopausal breast cancer defined by hormone receptor status.
Methods
The Breast Cancer Health Disparities Study pooled interview and anthropometric data from two large U.S. population-based case-control studies. We examined associations of overall and abdominal adiposity with risk of estrogen receptor and progesterone receptor positive (ER+PR+) and negative (ER−PR−) breast cancer in Hispanic and non-Hispanic White (NHW) women, calculating odds ratios (OR) and 95% confidence intervals (CI).
Results
Among Hispanics, young-adult and current body mass index (BMI) were inversely associated with both ER+PR+ and ER−PR− breast cancer. For ER+PR+ disease, risk was substantially reduced among those with elevated BMI throughout adulthood (OR=0.35, 95% CI=0.19-0.62). Height and height-to-waist ratio were positively associated with ER−PR− breast cancer. After adjustment for current BMI, two-fold increased risks were seen for large waist and hip circumferences, regardless of tumor receptor status. Genetic ancestry appeared to modify some of the associations with overall and abdominal adiposity. Among NHWs, findings for overall adiposity were similar to those for Hispanics, but there was no evidence of associations with abdominal adiposity.
Conclusions
Our findings for Hispanic women were generally similar to those reported for NHW women in other studies, with inverse associations for overall adiposity and positive associations for abdominal adiposity.
Impact
Abdominal obesity in young adulthood is an important risk factor for premenopausal breast cancer among Hispanic women.
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Pubmed ID:25352526
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Pubmed Central ID:PMC4294975
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Volume:24
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Issue:1
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