MATERNAL OCCUPATIONAL EXPOSURE TO POLYCYCLIC AROMATIC HYDROCARBONS AND RISK OF ORAL CLEFT-AFFECTED PREGNANCIES
Published Date:Nov 08 2012
Source:Cleft Palate Craniofac J. 50(3):337-346.
Corporate Authors:National Birth Defects Prevention Study
Pubmed Central ID:PMC4096036
Funding:L40 DE023736/DE/NIDCR NIH HHS/United States
P30 ES005605/ES/NIEHS NIH HHS/United States
R03 DE021739/DE/NIDCR NIH HHS/United States
U01 DD000494/DD/NCBDD CDC HHS/United States
Evaluate whether there is an association between maternal occupational exposure to polycyclic aromatic hydrocarbons (PAHs) and oral cleftsin offspring. This is the first human study of PAHs and clefts of which the authors are aware.
Data for 1997–2002 from the National Birth Defects Prevention Study, a large population-based case-control study in the US, were analyzed. Maternal telephone interviews yielded information on jobs held in the month before through three months after conception. Two industrial hygienists independently assessed occupational exposure to PAHs ; all jobs rated as exposed or with rating difficulty were reviewed with a third industrial hygienist to reach consensus on all exposure parameters. Logistic regression estimated crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for cleft lip with or without cleft palate (CL±P) and cleft palate alone (CP).
There were 2989 controls( 3.5% exposed), 805 cases of CL±P (5.8% exposed) and 439 cases of CP (4.6% exposed). The odds of maternal occupational exposure to PAH (any vs none) during pregnancy was increased for CL±P cases as compared with controls (OR 1.69, 95% CI 1.18–2.40); the OR was 1.47 (95% CI 1.02–2.12) adjusted for maternal education. There was a statistically significant adjusted exposure-response relationship for CL±P (ptrend = 0.02). ORs for CP were not statistically significant.
Maternal occupational exposure to PAHs was associated with increased risk of cleft lip with or without cleft palate in offspring.
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