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Graphene Oxide, But Not Fullerenes, Targets Immunoproteasomes and Suppresses Antigen Presentation by Dendritic Cells
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Aug 13 2012
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Source: Small. 2012; 9(0):1686-1690.
[PDF-822.14 KB]
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Alternative Title:Small
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Description:Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60 -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.
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Pubmed ID:22887961
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Pubmed Central ID:PMC4009732
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Volume:9
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Issue:0
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