Graphene Oxide, But Not Fullerenes, Targets Immunoproteasomes and Suppresses Antigen Presentation by Dendritic Cells

Tkach, Alexey V.; Yanamala, Naveena; Stanley, Shyla; Shurin, Michael R.; Shurin, Galina V.; Kisin, Elena R.; Murray, Ashley R.; Pareso, Samantha; Khaliullin, Timur; Kotchey, Gregg P.; Castranova, Vincent; Mathur, Sanjay; Fadeel, Bengt; Star, Alexander; Kagan, Valerian E.; Shvedova, Anna A.

doi:10.1002/smll.201201546

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Graphene Oxide, But Not Fullerenes, Targets Immunoproteasomes and Suppresses Antigen Presentation by Dendritic Cells

Published Date:

Aug 13 2012

Publisher's site:

http://dx.doi.org/10.1002/smll.201201546

Source:

Small. 2012; 9(0):1686-1690.

[PDF-822.14 KB]

Details:

Alternative Title:

Small

Personal Author:

Tkach, Alexey V. ; Yanamala, Naveena ; Stanley, Shyla ; Shurin, Michael R. ; Shurin, Galina V. ; ... More ▼

Description:

Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60 -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.

Subject:

[+]

Pubmed ID:

22887961

Pubmed Central ID:

PMC4009732

Document Type:

Journal Article

Funding:

R01 HL070755/HL/NHLBI NIH HHS/United States ; R01 ES020693/ES/NIEHS NIH HHS/United States ; R01 OH008282/OH/NIOSH CDC HHS/United States ; U19 AI068021/AI/NIAID NIH HHS/United States ; ES021068/ES/NIEHS NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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