Graphene Oxide, But Not Fullerenes, Targets Immunoproteasomes and Suppresses Antigen Presentation by Dendritic Cells

Details

• Alternative Title:
  Small
• Personal Author:
  Tkach, Alexey V. ; Yanamala, Naveena ; Stanley, Shyla ; Shurin, Michael R. ; Shurin, Galina V. ; Kisin, Elena R. ; Murray, Ashley R. ; Pareso, Samantha ; Khaliullin, Timur ; Kotchey, Gregg P. ; Castranova, Vincent ; Mathur, Sanjay ; Fadeel, Bengt ; Star, Alexander ; Kagan, Valerian E. ; Shvedova, Anna A.
• Description:
  Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60 -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines.
• Subjects:
  Animals Antigen Presentation Dendritic Cells Fullerenes Graphite Mice Oxides Proteasome Endopeptidase Complex
• Source:
  Small. 2012; 9(0):1686-1690.
• Pubmed ID:
  22887961
• Pubmed Central ID:
  PMC4009732
• Document Type:
  Journal Article
• Funding:
  R01 HL070755/HL/NHLBI NIH HHS/United States ; R01 ES020693/ES/NIEHS NIH HHS/United States ; R01 OH008282/OH/NIOSH CDC HHS/United States ; U19 AI068021/AI/NIAID NIH HHS/United States ; ES021068/ES/NIEHS NIH HHS/United States ; ES020693/ES/NIEHS NIH HHS/United States ; U19AI068021/AI/NIAID NIH HHS/United States ; HL70755/HL/NHLBI NIH HHS/United States ; R01 ES019304/ES/NIEHS NIH HHS/United States ; R21 ES021068/ES/NIEHS NIH HHS/United States ; ES019304/ES/NIEHS NIH HHS/United States
• Volume:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b948ec8558acbb3a267f40069e7566c5a256e032da7a415739965575bd26f8c8
• Download URL:
  https://stacks.cdc.gov/view/cdc/41955/cdc_41955_DS1.pdf
• File Type:
  [PDF - 822.14 KB ]