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Effects of General Medical Health on Alzheimer Progression: the Cache County Dementia Progression Study
  • Published Date:
    Jun 12 2012
  • Source:
    Int Psychogeriatr. 24(10):1561-1570.
Filetype[PDF - 306.03 KB]


Details:
  • Pubmed ID:
    22687143
  • Pubmed Central ID:
    PMC3573852
  • Funding:
    R01AG21136/AG/NIA NIH HHS/United States
    R15 AG037392/AG/NIA NIH HHS/United States
    P30 AG028377/AG/NIA NIH HHS/United States
    T32 AG027668/AG/NIA NIH HHS/United States
    U01 DD000698/DD/NCBDD CDC HHS/United States
    P50 AG005146/AG/NIA NIH HHS/United States
    R01 ES016669/ES/NIEHS NIH HHS/United States
    R01AG18712/AG/NIA NIH HHS/United States
    R01 MH085740/MH/NIMH NIH HHS/United States
    K24AG027841/AG/NIA NIH HHS/United States
    P30 AG013846/AG/NIA NIH HHS/United States
    R01HG02213/HG/NHGRI NIH HHS/United States
    R21 AG033769/AG/NIA NIH HHS/United States
    30AG028377/AG/NIA NIH HHS/United States
    K24 AG027841/AG/NIA NIH HHS/United States
    R01 HG002213/HG/NHGRI NIH HHS/United States
    R01AG11380/AG/NIA NIH HHS/United States
    U01 AG037526/AG/NIA NIH HHS/United States
    P30AG13846/AG/NIA NIH HHS/United States
    R01 AG021136/AG/NIA NIH HHS/United States
    R01 MH086881/MH/NIMH NIH HHS/United States
    R01 AG031272/AG/NIA NIH HHS/United States
    R01 AG011380/AG/NIA NIH HHS/United States
    R01 AG018712/AG/NIA NIH HHS/United States
    R01 AG031348/AG/NIA NIH HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    Background

    Several observational studies suggested a link between health status and rate of decline among individuals with Alzheimer’s disease (AD). We sought to quantify the relationship in a population-based study of incident AD, and to compare global comorbidity ratings to counts of comorbid conditions and medications as predictors of AD progression.

    Methods

    Results

    Health Status tended to fluctuate over time within individuals. None of the baseline medical variables (GMHR, comorbidities, non-psychiatric medications) were associated with differences in rates of decline in longitudinal linear mixed effects models. Over time, low GMHR ratings, but not comorbidities or medications, were associated with poorer outcomes (MMSE: β=−1.07 p=0.01; CDR-sb: β=1.79 p<0.001; NPI: β=4.57 p=0.01)

    Conclusions

    Given that time-varying GMHR, but not baseline GMHR, was associated with the outcomes, there is likely a dynamic relationship between medical and cognitive health. GMHR is a more sensitive measure of health than simple counts of comorbidities or medications. Since health status is a potentially modifiable risk factor, further study is warranted.