Effects of General Medical Health on Alzheimer Progression: the Cache County Dementia Progression Study

Leoutsakos, Jeannie-Marie S.; Han, Dingfen; Mielke, Michelle M.; Forrester, Sarah N.; Tschanz, JoAnn T.; Corcoran, Chris D.; Green, Robert C.; Norton, Maria C.; Welsh-Bohmer, Kathleen A.; Lyketsos, Constantine G.

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Effects of General Medical Health on Alzheimer Progression: the Cache County Dementia Progression Study

Published Date:

Jun 12 2012

Source:

Int Psychogeriatr. 24(10):1561-1570.

[PDF-306.03 KB]

Details:

Personal Authors:

Leoutsakos, Jeannie-Marie S. ; Han, Dingfen ; Mielke, Michelle M. ; Forrester, Sarah N. ; Tschanz, JoAnn T. ; ... More ▼

Keywords:

[+]

Pubmed ID:

22687143

Pubmed Central ID:

PMC3573852

Description:

Background

Several observational studies suggested a link between health status and rate of decline among individuals with Alzheimer’s disease (AD). We sought to quantify the relationship in a population-based study of incident AD, and to compare global comorbidity ratings to counts of comorbid conditions and medications as predictors of AD progression.

Methods

Results

Health Status tended to fluctuate over time within individuals. None of the baseline medical variables (GMHR, comorbidities, non-psychiatric medications) were associated with differences in rates of decline in longitudinal linear mixed effects models. Over time, low GMHR ratings, but not comorbidities or medications, were associated with poorer outcomes (MMSE: β=−1.07 p=0.01; CDR-sb: β=1.79 p<0.001; NPI: β=4.57 p=0.01)

Conclusions

Given that time-varying GMHR, but not baseline GMHR, was associated with the outcomes, there is likely a dynamic relationship between medical and cognitive health. GMHR is a more sensitive measure of health than simple counts of comorbidities or medications. Since health status is a potentially modifiable risk factor, further study is warranted.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Supporting Files:

nihms-427930.nxml

application/octet-stream

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