Atomoxetine Increases Fronto-Parietal Functional MRI Activation in Attention-Deficit/Hyperactivity Disorder: A Pilot Study

Details

• Alternative Title:
  Psychiatry Res
• Personal Author:
  Bush, George ; Holmes, Jennifer ; Shin, Lisa M. ; Surman, Craig ; Makris, Nikos ; Mick, Eric ; Seidman, Larry J. ; Biederman, Joseph
• Description:
  We hypothesized that atomoxetine (ATMX) would produce similar brain effects in attention-deficit/hyperactivity disorder (ADHD) as those of methylphenidate (MPH). Eleven ADHD adults performed the Multi-Source Interference Task (MSIT) during functional magnetic resonance imaging (fMRI) at baseline and after 6 weeks of ATMX treatment. ATMX was associated with increased fMRI activation of dorsolateral prefrontal cortex, parietal cortex and cerebellum but not dorsal anterior midcingulate cortex (daMCC). These results suggest that ATMX and MPH have similar but not identical brain effects.
• Subjects:
  Adrenergic Uptake Inhibitors Adult Atomoxetine Hydrochloride Attention Deficit Disorder With Hyperactivity Frontal Lobe Humans Magnetic Resonance Imaging Nerve Net Parietal Lobe Pilot Projects Propylamines

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• Source:
  Psychiatry Res. 2012; 211(1):88-91.
• Pubmed ID:
  23146254
• Pubmed Central ID:
  PMC3557757
• Document Type:
  Journal Article
• Funding:
  P41 RR014075/RR/NCRR NIH HHS/United States ; R01 DP000339/DP/NCCDPHP CDC HHS/United States ; R01 MH062152/MH/NIMH NIH HHS/United States
• Volume:
  211
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:39817d1bdd2e603d4c6713f4910702761c418ce3dda7c0561b0e1cf82da85572
• Download URL:
  https://stacks.cdc.gov/view/cdc/41876/cdc_41876_DS1.pdf
• File Type:
  [PDF - 1.15 MB ]