Atomoxetine Increases Fronto-Parietal Functional MRI Activation in Attention-Deficit/Hyperactivity Disorder: A Pilot Study
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Published Date:Nov 10 2012
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Publisher's site:
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Source:Psychiatry Res. 2012; 211(1):88-91.
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Pubmed ID:23146254
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Pubmed Central ID:PMC3557757
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Description:We hypothesized that atomoxetine (ATMX) would produce similar brain effects in attention-deficit/hyperactivity disorder (ADHD) as those of methylphenidate (MPH). Eleven ADHD adults performed the Multi-Source Interference Task (MSIT) during functional magnetic resonance imaging (fMRI) at baseline and after 6 weeks of ATMX treatment. ATMX was associated with increased fMRI activation of dorsolateral prefrontal cortex, parietal cortex and cerebellum but not dorsal anterior midcingulate cortex (daMCC). These results suggest that ATMX and MPH have similar but not identical brain effects.
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Funding:P41 RR014075/RR/NCRR NIH HHS/United States
R01 DP000339/DP/NCCDPHP CDC HHS/United States
R01 MH062152/MH/NIMH NIH HHS/United States
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