Impact of Maternal Immunization on Influenza Hospitalizations in Infants
Published Date:Feb 23 2011
Source:Am J Obstet Gynecol. 204(6 Suppl 1):S141-S148.
Practice Guidelines As Topic
Pregnancy Complications, Infectious
Pubmed Central ID:PMC3111909
Funding:U01 IP000147/IP/NCIRD CDC HHS/United States
K23 AI065805/AI/NIAID NIH HHS/United States
K23 AI065805-06/AI/NIAID NIH HHS/United States
U01 IP000022/IP/NCIRD CDC HHS/United States
U01 IP000017/IP/NCIRD CDC HHS/United States
To determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants <6 months old.
Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 U.S. counties from November-April during the 2002–2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses.
Among 1510 hospitalized infants <6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted OR= 0.53, 95%CI 0.32–0.88 and adjusted OR=0.52, 95%0.30–0.91).
Infants of vaccinated mothers were 45%–48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.
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