Early Life Antibiotic Exposure Is Not Associated with Growth in Young Children of Vellore, India
Published Date:Sep 12 2015
Source:J Pediatr. 167(5):1096-102.e3.
Pubmed Central ID:PMC5030490
Funding:D43-TW007392/TW/FIC NIH HHS/United States
D43 TW007392/TW/FIC NIH HHS/United States
DP2 HD084070/HD/NICHD NIH HHS/United States
DP2-HD084070/DP/NCCDPHP CDC HHS/United States
5-R01-AI072222/AI/NIAID NIH HHS/United States
1-R56-AI108515/AI/NIAID NIH HHS/United States
R01 AI072222/AI/NIAID NIH HHS/United States
R56 AI108515/AI/NIAID NIH HHS/United States
5-T32-AI070114-08/AI/NIAID NIH HHS/United States
T32 AI070114/AI/NIAID NIH HHS/United States
To estimate the effects of antibiotic exposures in the first 6 months of life on short- and long-term growth.
In a prospective observational cohort study of 497 children from Vellore, India, we estimated short-term effects of antibiotics during the first 6 months using longitudinal general linear regression to model weight-forage, height-for-age, and weight-for-height z-scores in monthly intervals. To estimate long-term effects, we modeled growth from 6 months to 3 years as a function of antibiotic use in the first 6 months. We also estimated the effects of antibiotics on the monthly relative risks of underweight, stunting, and wasting in the first 6 months and to 3 years.
Underweight, stunting, and wasting were common in this population: 31%, 32%, and 15% on average after 6 months of age, respectively. There was no association between antibiotic exposures before 6 months and growth during that period. From 6 months to 3 years, adjusted absolute differences in weight and height were small (approximately −100 g and no more than −2 mm overall, respectively) and not statistically significant.
Antibiotic exposures early in life were not associated with increased or decreased growth. The combination of malnutrition and recurrent illness likely complicate the relationship between antibiotic exposures and growth among children in low and middle-income countries.
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