Early Life Antibiotic Exposure Is Not Associated with Growth in Young Children of Vellore, India

Details

• Alternative Title:
  J Pediatr
• Personal Author:
  Rogawski, Elizabeth T. ; Westreich, Daniel J. ; Adair, Linda S. ; Becker-Dreps, Sylvia ; Sandler, Robert S. ; Sarkar, Rajiv ; Kattula, Deepthi ; Ward, Honorine D. ; Meshnick, Steven ; Kang, Gagandeep
• Description:
  Objectives
  
  To estimate the effects of antibiotic exposures in the first 6 months of life on short- and long-term growth.
  
  Study design
  
  In a prospective observational cohort study of 497 children from Vellore, India, we estimated short-term effects of antibiotics during the first 6 months using longitudinal general linear regression to model weight-forage, height-for-age, and weight-for-height z-scores in monthly intervals. To estimate long-term effects, we modeled growth from 6 months to 3 years as a function of antibiotic use in the first 6 months. We also estimated the effects of antibiotics on the monthly relative risks of underweight, stunting, and wasting in the first 6 months and to 3 years.
  
  Results
  
  Underweight, stunting, and wasting were common in this population: 31%, 32%, and 15% on average after 6 months of age, respectively. There was no association between antibiotic exposures before 6 months and growth during that period. From 6 months to 3 years, adjusted absolute differences in weight and height were small (approximately −100 g and no more than −2 mm overall, respectively) and not statistically significant.
  
  Conclusions
  
  Antibiotic exposures early in life were not associated with increased or decreased growth. The combination of malnutrition and recurrent illness likely complicate the relationship between antibiotic exposures and growth among children in low and middle-income countries.
  
  
• Subjects:
  Anti-Bacterial Agents Body Height Body Weight Child, Preschool Cryptosporidiosis Female Follow-Up Studies Growth Disorders Humans Incidence India Infant Infant, Newborn Male Prospective Studies Risk Factors Time Factors

  More +
• Source:
  J Pediatr. 167(5):1096-102.e3
• Pubmed ID:
  26372535
• Pubmed Central ID:
  PMC5030490
• Document Type:
  Journal Article
• Funding:
  D43-TW007392/TW/FIC NIH HHSUnited States/ ; D43 TW007392/TW/FIC NIH HHSUnited States/ ; DP2 HD084070/HD/NICHD NIH HHSUnited States/ ; DP2-HD084070/DP/NCCDPHP CDC HHSUnited States/ ; 5-R01-AI072222/AI/NIAID NIH HHSUnited States/ ; 1-R56-AI108515/AI/NIAID NIH HHSUnited States/ ; R01 AI072222/AI/NIAID NIH HHSUnited States/ ; R56 AI108515/AI/NIAID NIH HHSUnited States/ ; 5-T32-AI070114-08/AI/NIAID NIH HHSUnited States/ ; T32 AI070114/AI/NIAID NIH HHSUnited States/ ; P2C HD050924/HD/NICHD NIH HHSUnited States/
• Volume:
  167
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:243de7ac95da132f81b520af34a57537c5d69a4a0d24cd3d87870d59603843c8
• Download URL:
  https://stacks.cdc.gov/view/cdc/41436/cdc_41436_DS1.pdf
• File Type:
  [PDF - 454.01 KB ]