Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an analysis of the United States Assisted Reproductive Technology Surveillance Data, 2011–2012

Details

• Alternative Title:
  Fertil Steril
• Personal Author:
  Chang, Jeani ; Boulet, Sheree L. ; Jeng, Gary ; Flowers, Lisa ; Kissin, Dmitry M.
• Corporate Authors:
  National Center for Chronic Disease Prevention and Health Promotion.(U.S.), Division of Reproductive Health.
• Description:
  Objective
  
  To assess the characteristics of IVF cycles for which preimplantation genetic diagnosis (PGD) was used and to evaluate indications for PGD and treatment outcomes associated with this procedure as compared with cycles without PGD with the data from the U.S. National ART Surveillance System.
  
  Design
  
  Retrospective cohort study.
  
  Setting
  
  None.
  
  Patient(s)
  
  Fresh autologous cycles that involved transfer of at least one embryo at blastocyst when available.
  
  Intervention(s)
  
  Main Outcome Measure(s)
  
  PGD indications and age-specific reproductive outcomes.
  
  Result(s)
  
  There were a total of 97,069 non-PGD cycles and 9,833 PGD cycles: 55.6% were performed for aneuploidy screening (PGD Aneuploidy), 29.1% for other reasons (PGD Other), and 15.3% for genetic testing (PGD Genetic). In comparison to non-PGD cycles, PGD Aneuploidy cycles showed a decreased odds of miscarriage among women 35–37 years (adjusted odds ratio [aOR] 0.62; 95% CI, 0.45–0.87) and women >37 years (aOR 0.55; 95% CI, 0.43–0.70); and an increased odds of clinical pregnancy (aOR 1.18; 95% CI, 1.05–1.34), live-birth delivery (aOR 1.43; 95% CI, 1.26–1.62), and multiple-birth delivery (aOR 1.98; 95% CI, 1.52–2.57) among women >37 years.
  
  Conclusion(s)
  
  Aneuploidy screening was the most common indication for PGD. Use of PGD was not observed to be associated with an increased odds of clinical pregnancy or live birth for women <35 years. PGD for aneuploidy was associated with a decreased odds of miscarriage for women >35 years, but an increased odds of a live-birth and a multiple live-birth delivery among women >37 years.
  
  
• Subjects:
  Abortion, Spontaneous Adult Age Factors Chromosome Aberrations Databases, Factual Female Fertility Fertilization In Vitro Genetic Counseling Genetic Diseases, Inborn Genetic Testing Humans Infertility Live Birth Logistic Models Multivariate Analysis Odds Ratio Predictive Value Of Tests Pregnancy Pregnancy, Multiple Pregnancy Rate Preimplantation Diagnosis Retrospective Studies Risk Assessment Risk Factors Treatment Outcome

  More +
• Source:
  Fertil Steril. 105(2):394-400.
• Series:
  Assisted Reproductive Technology (ART)
• Subseries:
  Assisted Reproductive Technology Publication
• Pubmed ID:
  26551441
• Pubmed Central ID:
  PMC5023328
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Genre:
  Research Paper
• Place as Subject:
  United States
• CIO:
  National Center for Chronic Disease Prevention and Health Promotion
• Division:
  Division of Reproductive Health
• Topic:
  Reproductive Health ; Assisted Reproductive Technology
• Location:
  North America
• Volume:
  105
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a3be9c453b4db6ea3c9165014e0566f8783035a1da1573a75c49fd679a990a2484b22e0d29a300330cb9f76b23f9c3998a77f9eb74e24023313c5d2c22974457
• Download URL:
  https://stacks.cdc.gov/view/cdc/41337/cdc_41337_DS1.pdf
• File Type:
  [PDF - 84.50 KB ]