Details:

Alternative Title:
Sci Rep
Publisher's site:
http://dx.doi.org/10.1038/srep18802
Personal Author:
Austin, Christine ; Smith, Tanya M. ; Farahani, Ramin M. Z. ; Hinde, Katie ; Carter, Elizabeth A. ; ... More +
Austin, Christine ; Smith, Tanya M. ; Farahani, Ramin M. Z. ; Hinde, Katie ; Carter, Elizabeth A. ; Lee, Joonsup ; Lay, Peter A. ; Kennedy, Brendan J. ; Sarrafpour, Babak ; Wright, Rosalind J. ; Wright, Robert O. ; Arora, Manish ; Less -
Description:
Early life stress can disrupt development and negatively impact long-term health trajectories. Reconstructing histories of early life exposure to external stressors is hampered by the absence of retrospective time-specific biomarkers. Defects in tooth enamel have been used to reconstruct stress but the methods used are subjective and do not identify the specific biological systems impacted by external stressors. Here we show that external physical and social stressors impart biochemical signatures in primate teeth that can be retrieved to objectively reconstruct the timing of early life developmental disruptions. Using teeth from captive macaques, we uncovered elemental imprints specific to disruptions of skeletal growth, including major disruptions in body weight trajectory and moderate to severe illnesses. Discrete increases in heat shock protein-70 expression in dentine coincided with elemental signatures, confirming that elemental signals were associated with activation of stress-related pathways. To overcome limitations of conventional light-microscopic analysis, we used high resolution Raman microspectral imaging to identify structural and compositional alterations in enamel and dentine that coincided with elemental signatures and with detailed medical and behavioural data. Integrating these objective biochemical markers with temporal mapping of teeth enables the retrospective study of early life developmental disruptions and their ensuing health sequelae.
Subject:
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Animals
Biomarkers
Dentin
HSP70 Heat-Shock Proteins
Multimodal Imaging
Primates
Retrospective Studies
Spectrum Analysis, Raman
Stress, Physiological
Stress, Psychological
Tooth

Source:
Sci Rep. 2016; 6.
Pubmed ID:
26727334
Pubmed Central ID:
PMC4698674
Document Type:
Journal Article ;
Funding:
1DP2ES025453/DP/NCCDPHP CDC HHS/United States ; 4R00ES019597/ES/NIEHS NIH HHS/United States ; P51OD011107/OD/NIH HHS/United States ; P51RR000169/RR/NCRR NIH HHS/United States ;
1DP2ES025453/DP/NCCDPHP CDC HHS/United States ; 4R00ES019597/ES/NIEHS NIH HHS/United States ; P51OD011107/OD/NIH HHS/United States ; P51RR000169/RR/NCRR NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9719ed8e8009b51f4d7e4efe2ccede4882dcf34c485665e3c710fad97091665e
File Type:

Supporting Files

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