Metabolic Health Has Greater Impact on Diabetes than Simple Overweight/Obesity in Mexican Americans

Wu, Shenghui; Fisher-Hoch, Susan P.; Reninger, Belinda; Vatcheva, Kristina; McCormick, Joseph B.

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Metabolic Health Has Greater Impact on Diabetes than Simple Overweight/Obesity in Mexican Americans

Supporting Files

Jan 10 2016
By Wu, Shenghui ; Fisher-Hoch, Susan P. ; Reninger, Belinda ; ...

File Language:

English

Details

Alternative Title:

J Diabetes Res
Personal Author:

Wu, Shenghui ; Fisher-Hoch, Susan P. ; Reninger, Belinda ; Vatcheva, Kristina ; McCormick, Joseph B.
Description:

To compare the risk for diabetes in each of 4 categories of metabolic health and BMI.|Participants were drawn from the Cameron County Hispanic Cohort, a randomly selected Mexican American cohort in Texas on the US-Mexico border. Subjects were divided into 4 phenotypes according to metabolic health and BMI: metabolically healthy normal weight, metabolically healthy overweight/obese, metabolically unhealthy normal weight, and metabolically unhealthy overweight/obese. Metabolic health was defined as having less than 2 metabolic abnormalities. Overweight/obese status was assessed by BMI higher than 25 kg/m(2). Diabetes was defined by the 2010 ADA definition or by being on a diabetic medication.|The odds ratio for diabetes risk was 2.25 in the metabolically healthy overweight/obese phenotype (95% CI 1.34, 3.79), 3.78 (1.57, 9.09) in the metabolically unhealthy normal weight phenotype, and 5.39 (3.16, 9.20) in metabolically unhealthy overweight/obese phenotype after adjusting for confounding factors compared with the metabolically healthy normal weight phenotype.|Metabolic health had a greater effect on the increased risk for diabetes than overweight/obesity. Greater focus on metabolic health might be a more effective target for prevention and control of diabetes than emphasis on weight loss alone.
Subjects:

Age Factors Diabetes Mellitus Diabetes Mellitus / Etiology Female Humans Male Mexican Americans Middle Aged Obesity Overweight
Source:

J Diabetes Res. 2016; 2016.
Pubmed ID:

26881247
Pubmed Central ID:

PMC4736910
Document Type:

Journal Article
Funding:

1U54RR023417-01/RR/NCRR NIH HHS/United States ; MD000170 P20/MD/NIMHD NIH HHS/United States ; R01 DP000210-01/DP/NCCDPHP CDC HHS/United States ; UL1 TR000371/TR/NCATS NIH HHS/United States ; UL1 TR001120/TR/NCATS NIH HHS/United States
Volume:

2016
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:f91a560bd89a654072dae6d269199ea81a0fd6c3ad8c4a4e966166bb4c88c432
Download URL:

https://stacks.cdc.gov/view/cdc/41031/cdc_41031_DS1.pdf
File Type:

[PDF - 666.60 KB ]

File Language:

English

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