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Metabolic Health Has Greater Impact on Diabetes than Simple Overweight/Obesity in Mexican Americans
  • Published Date:
    Jan 10 2016
  • Source:
    J Diabetes Res. 2016; 2016.
Filetype[PDF-666.60 KB]

  • Pubmed ID:
  • Pubmed Central ID:
  • Description:
    To compare the risk for diabetes in each of 4 categories of metabolic health and BMI.|Participants were drawn from the Cameron County Hispanic Cohort, a randomly selected Mexican American cohort in Texas on the US-Mexico border. Subjects were divided into 4 phenotypes according to metabolic health and BMI: metabolically healthy normal weight, metabolically healthy overweight/obese, metabolically unhealthy normal weight, and metabolically unhealthy overweight/obese. Metabolic health was defined as having less than 2 metabolic abnormalities. Overweight/obese status was assessed by BMI higher than 25 kg/m(2). Diabetes was defined by the 2010 ADA definition or by being on a diabetic medication.|The odds ratio for diabetes risk was 2.25 in the metabolically healthy overweight/obese phenotype (95% CI 1.34, 3.79), 3.78 (1.57, 9.09) in the metabolically unhealthy normal weight phenotype, and 5.39 (3.16, 9.20) in metabolically unhealthy overweight/obese phenotype after adjusting for confounding factors compared with the metabolically healthy normal weight phenotype.|Metabolic health had a greater effect on the increased risk for diabetes than overweight/obesity. Greater focus on metabolic health might be a more effective target for prevention and control of diabetes than emphasis on weight loss alone.

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  • Funding:
    1U54RR023417-01/RR/NCRR NIH HHS/United States
    MD000170 P20/MD/NIMHD NIH HHS/United States
    R01 DP000210-01/DP/NCCDPHP CDC HHS/United States
    UL1 TR000371/TR/NCATS NIH HHS/United States
    UL1 TR001120/TR/NCATS NIH HHS/United States
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