Details:

Alternative Title:
Diabet Med
Personal Author:
Sauder, KA ; Starling, AP ; Shapiro, AL ; Kaar, JL ; Ringham, BM ; ... More +
Sauder, KA ; Starling, AP ; Shapiro, AL ; Kaar, JL ; Ringham, BM ; Glueck, DH ; Leiferman, JA ; Siega-Riz, AM ; Dabelea, D Less -
Description:
Aims

Prenatal dysglycaemia is associated with adverse maternal and offspring outcomes. This study examined the association between dysglycaemia and multiple modifiable factors measured during pregnancy.

Methods

The Healthy Start Study collected self-reported data on modifiable factors in early and mid-pregnancy (median 17 and 27 weeks gestation, respectively) from 832 women. Women received 1 point for each optimal modifiable factor: diet quality (Healthy Eating Index ≥64), physical activity level (estimated energy expenditure ≥170 MET-hours/week), and mental health status (Perceived Stress <6 and Edinburgh Postnatal Depression <13). Dysglycaemia during pregnancy was defined as an abnormal glucose challenge, ≥1 abnormal results on an oral glucose tolerance test, or a clinical diagnosis of gestational diabetes. Logistic regression models estimated odds ratios for dysglycaemia as a function of each factor and the total score, adjusted for age, race/ethnicity, pre-pregnant body mass index, history of gestational diabetes, and family history of type 2 diabetes.

Results

In individual analyses, only physical activity was significantly associated with a reduced risk of dysglycaemia (adjusted OR 0.67, 95%CI 0.44–1.00). We observed a significant, dose-response association between increasing numbers of optimal factors and odds of dysglycaemia (adjusted p=0.01). Compared to having no optimal modifiable factors, having all 3 was associated with a 73% reduced risk of dysglycaemia (adjusted OR 0.27, 95%CI 0.08–0.95).

Conclusions

An increasing number of positive modifiable factors in pregnancy was associated with a dose-response reduction in risk of dysglycaemia. Our results support the hypothesis that modifiable factors in pregnancy are associated with the risk of prenatal dysglycaemia.


Subjects:
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Adult Article Cohort Studies Colorado Exercise Female Glucose Metabolism Disorders Healthy Diet Healthy Lifestyle Humans Infant, Newborn Infant, Newborn, Diseases Male Maternal Nutritional Physiological Phenomena Mental Health Pregnancy Pregnancy Complications Prospective Studies Risk Self Report Young Adult
Source:
Diabet Med. 33(5):663-667.
Pubmed ID:
26872289
Pubmed Central ID:
PMC4883104
Document Type:
Journal Article
Funding:
T32 DK007658/DK/NIDDK NIH HHS/United States ; R01 DK076648/DK/NIDDK NIH HHS/United States ; R01 DK076648-DD/DD/NCBDD CDC HHS/United States ; UL1 TR001082/TR/NCATS NIH HHS/United States ; P30 DK056350/DK/NIDDK NIH HHS/United States ; ... More +
T32 DK007658/DK/NIDDK NIH HHS/United States ; R01 DK076648/DK/NIDDK NIH HHS/United States ; R01 DK076648-DD/DD/NCBDD CDC HHS/United States ; UL1 TR001082/TR/NCATS NIH HHS/United States ; P30 DK056350/DK/NIDDK NIH HHS/United States ; P2C HD050924/HD/NICHD NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:93926d7f8541282cd29cd01d208dcc1caa75191858732eaddb5baf440f3499d6
Download URL:
https://stacks.cdc.gov/view/cdc/40996/cdc_40996_DS1.pdf
File Type:

Supporting Files

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