Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases

Details

• Alternative Title:
  BMC Urol
• Personal Author:
  Chen, Zhaohui ; Kim, Jayoung
• Description:
  Background
  
  Assays of molecular biomarkers in urine are non-invasive compared to other body fluids and can be easily repeated. Based on the hypothesis that the secreted markers from the diseased organs may locally release into the body fluid in the vicinity of the injury, urine-based assays have been considered beneficial to monitoring bladder health and urological diseases. The urine proteome is much less complex than the serum and tissues, but nevertheless can contain biomarkers for diagnosis and prognosis of diseases. The urine metabolome has a much higher number and concentration of low-molecular metabolites than the serum or tissues, with a far lower lipid concentration, yet informs directly about dietary and microbial metabolism.
  
  Discussion
  
  We here discuss the use of mass spectrometry-based proteomics and metabolomics for urine biomarker assays, specifically with respect to the underlying mechanisms that trigger the pathological condition.
  
  Conclusion
  
  Molecular biomarker profiles, based on proteomics and metabolomics studies, reliably distinguish patients from healthy controls, stratify sub-populations with respect to treatment options, and predict therapeutic response of patients with urological disease.
  
  
• Subjects:
  Bladder Diseases Metabolomics Proteomics Review Urinary Biomarkers
• Source:
  BMC Urol. 16.
• Pubmed ID:
  27000794
• Pubmed Central ID:
  PMC4802825
• Document Type:
  Journal Article
• Funding:
  1R01DK100974/DK/NIDDK NIH HHS/United States ; 1U01DK103260/DK/NIDDK NIH HHS/United States ; 1U01DP006079/DP/NCCDPHP CDC HHS/United States ; U24 DK097154/DK/NIDDK NIH HHS/United States ; UL1TR000124/TR/NCATS NIH HHS/United States
• Volume:
  16
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fad6a387c2cedc1a0902b9174fddaf7ee10e6d6715d687e7d08798bfef431c18
• Download URL:
  https://stacks.cdc.gov/view/cdc/40957/cdc_40957_DS1.pdf
• File Type:
  [PDF - 1.04 MB ]