Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study

Details

• Alternative Title:
  BMC Cancer
• Personal Author:
  Park, Hannah Lui ; Ziogas, Argyrios ; Chang, Jenny ; Desai, Bhumi ; Bessonova, Leona ; Garner, Chad ; Lee, Eunjung ; Neuhausen, Susan L. ; Wang, Sophia S. ; Ma, Huiyan ; Clague, Jessica ; Reynolds, Peggy ; Lacey, James V. ; Bernstein, Leslie ; Anton-Culver, Hoda
• Description:
  Background
  
  The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one’s subtype-specific breast cancer risk when considering chemoprevention. A number of single nucleotide polymorphisms (SNPs), including one in caspase-8 (CASP8), have been previously associated with risk of developing breast cancer. Because caspase-8 is an important protein involved in receptor-mediated apoptosis whose activity is affected by estrogen, we hypothesized that additional SNPs in CASP8 could be associated with breast cancer risk, perhaps in a subtype-specific manner.
  
  Methods
  
  Twelve tagging SNPs of CASP8 were analyzed in a nested case control study (1,353 cases and 1,384 controls) of non-Hispanic white women participating in the California Teachers Study. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for each SNP using all, estrogen receptor (ER)-positive, ER-negative, human epidermal growth factor receptor 2 (HER2)-positive, and HER2-negative breast cancers as separate outcomes.
  
  Results
  
  Several SNPs were associated with all, ER-positive, and HER2-positive breast cancers; however, after correcting for multiple comparisons (i.e., p < 0.0008), only rs2293554 was statistically significantly associated with HER2-positive breast cancer (OR = 1.98, 95 % CI 1.34-2.92, uncorrected p = 0.0005).
  
  Conclusions
  
  While our results for CASP8 SNPs should be validated in other cohorts with subtype-specific information, we conclude that some SNPs in CASP8 are associated with subtype-specific breast cancer risk. This study contributes to our understanding of CASP8 SNPs and breast cancer risk by subtype.
  
  Electronic supplementary material
  
  The online version of this article (doi:10.1186/s12885-015-2036-9) contains supplementary material, which is available to authorized users.
  
  
• Subjects:
  Breast Cancer Caspase-8 Research Article Single Nucleotide Polymorphism
• Source:
  BMC Cancer. 16.
• Pubmed ID:
  26758508
• Pubmed Central ID:
  PMC4711015
• Document Type:
  Journal Article
• Funding:
  HHSN261201000034C/PHS HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000140C/PHS HHS/United States ; R01 CA77398/CA/NCI NIH HHS/United States ; U58DP003862-01/DP/NCCDPHP CDC HHS/United States
• Volume:
  16
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ca924e8ed27495775dec75d002eafc8f2802fb05a22e7d8534d4760e7e4e369a
• Download URL:
  https://stacks.cdc.gov/view/cdc/40955/cdc_40955_DS1.pdf
• File Type:
  [PDF - 462.88 KB ]