Maternal Hemoglobin Concentration during Gestation and Risk of Anemia in Infancy: Secondary Analysis of a Randomized Controlled Trial

Details

• Alternative Title:
  J Pediatr
• Personal Author:
  Zhang, Yiting ; Jin, Lei ; Liu, Jian-meng ; Ye, Rongwei ; Ren, Aiguo
• Description:
  Objective
  
  To examine the relationship between maternal hemoglobin (Hb) concentration and the risk of anemia in infancy.
  
  Study design
  
  This analysis included 17,193 women who entered the trial when they were 20 years of age or older, no more than 20 weeks of gestation, had mild or no anemia, and delivered singleton live births. Maternal Hb concentrations were measured in the first trimester and during 24-28 weeks of gestation; infant Hb concentrations were measured at 5-7 months and 11-13 months of life. The associations between maternal Hb concentrations and infant Hb concentrations were examined.
  
  Results
  
  Maternal Hb concentrations measured during 24-28 weeks of gestation, but not in the first trimester, were correlated with infant Hb concentrations measured at either of the two post-partum periods. The risk of infant anemia at 5-7 months increased when maternal Hb concentration was ≤109 g/L during 24-28 weeks of gestation ([AOR: 1.95, 95% CI: 1.59-2.40] and 11-13 months [AOR: 1.72, 95% CI: 1.36-2.18]); whereas the risk of anemia during 5-7 months as well as 11-13 months in infancy decreased when maternal Hb level at 24-28 weeks of gestation was 120-129 g/L (AOR for 5-7 months: 0.74, 95% CI: 0.64-0.85; AOR for 11-13 months: 0.72, 95% CI: 0.61-0.85) or ≥130 g/L (AOR for 5-7 months: 0.75, 95% CI: 0.63-0.90; AOR for 11-13 months: 0.89, 95% CI: 0.73-1.08).
  
  Conclusion
  
  Low maternal Hb concentration during 24-28 weeks of gestation was associated with an increased risk of anemia in infancy, whereas high maternal Hb concentration was associated with a reduced risk of anemia.
  
  
• Subjects:
  Adult Anemia Article Biomarkers Female Follow-Up Studies Gestation Hemoglobin Hemoglobins Humans Infant Male Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Prenatal Exposure Delayed Effects Prospective Studies Protective Factors Risk Factors

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• Source:
  J Pediatr. 175:106-110.e2
• Pubmed ID:
  27263403
• Pubmed Central ID:
  PMC4981517
• Document Type:
  Journal Article
• Funding:
  U01 DD000293/DD/NCBDD CDC HHSUnited States/
• Volume:
  175
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:926a34be588941a309580811fe7c08f32ddcf1650987d568950efaa7428f9e2d
• Download URL:
  https://stacks.cdc.gov/view/cdc/40892/cdc_40892_DS1.pdf
• File Type:
  [PDF - 842.16 KB ]