Details:

Alternative Title:
J Pediatr
Publisher's site:
http://dx.doi.org/10.1016/j.jpeds.2016.05.011
Personal Author:
Zhang, Yiting ; Jin, Lei ; Liu, Jian-meng ; Ye, Rongwei ; Ren, Aiguo
Zhang, Yiting ; Jin, Lei ; Liu, Jian-meng ; Ye, Rongwei ; Ren, Aiguo Less -
Description:
Objective

To examine the relationship between maternal hemoglobin (Hb) concentration and the risk of anemia in infancy.

Study design

This analysis included 17,193 women who entered the trial when they were 20 years of age or older, no more than 20 weeks of gestation, had mild or no anemia, and delivered singleton live births. Maternal Hb concentrations were measured in the first trimester and during 24-28 weeks of gestation; infant Hb concentrations were measured at 5-7 months and 11-13 months of life. The associations between maternal Hb concentrations and infant Hb concentrations were examined.

Results

Maternal Hb concentrations measured during 24-28 weeks of gestation, but not in the first trimester, were correlated with infant Hb concentrations measured at either of the two post-partum periods. The risk of infant anemia at 5-7 months increased when maternal Hb concentration was ≤109 g/L during 24-28 weeks of gestation ([AOR: 1.95, 95% CI: 1.59-2.40] and 11-13 months [AOR: 1.72, 95% CI: 1.36-2.18]); whereas the risk of anemia during 5-7 months as well as 11-13 months in infancy decreased when maternal Hb level at 24-28 weeks of gestation was 120-129 g/L (AOR for 5-7 months: 0.74, 95% CI: 0.64-0.85; AOR for 11-13 months: 0.72, 95% CI: 0.61-0.85) or ≥130 g/L (AOR for 5-7 months: 0.75, 95% CI: 0.63-0.90; AOR for 11-13 months: 0.89, 95% CI: 0.73-1.08).

Conclusion

Low maternal Hb concentration during 24-28 weeks of gestation was associated with an increased risk of anemia in infancy, whereas high maternal Hb concentration was associated with a reduced risk of anemia.


Subject:
[+]
Adult
Anemia
Article
Biomarkers
Female
Follow-Up Studies
Gestation
Hemoglobin
Hemoglobins
Humans
Infant
Male
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prenatal Exposure Delayed Effects
Prospective Studies
Protective Factors
Risk Factors
Infant

Source:
J Pediatr. 175:106-110.e2.
Pubmed ID:
27263403
Pubmed Central ID:
PMC4981517
Document Type:
Journal Article
Funding:
U01 DD000293/DD/NCBDD CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:926a34be588941a309580811fe7c08f32ddcf1650987d568950efaa7428f9e2d
File Type:

Supporting Files

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