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Revised research protocol for a study of cancer among United States firefighters

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  • Description:
    The primary objective of the project is to clarify the relationship between firefighter occupational exposures and cancer. The project will improve upon previously published firefighter studies by 1) significantly increasing the study cohort size and person-years at risk, and 2) using a more detailed exposure surrogate metric in both the mortality and incidence analyses than are found in most previous studies. These improvements will increase the precision of disease risk estimates. The objectives of the study are 1) to establish a pooled cohort of career firefighters from both suburban and large city fire departments to study the relationship between firefighter occupational exposures and cancer, 2) to conduct a retrospective mortality study among the cohort of career firefighters, 3) to determine the incidence of cancer among the firefighter cohort members, 4) to examine the relationship between occupational exposures and cause-specific mortality and cancer incidence among firefighters. Study results and recommendations will be translated and communicated through collaboration with the International Association of Firefighters (IAFF), the International Association of Fire Chiefs (IAFC), the Firefighter Cancer Support Network, labor and management from each participating fire department, and other firefighter organizations (e.g., the United States Fire Administration, National Volunteer Fire Council, and the National Fire Protection Association). All manuscripts will be submitted to peer-reviewed scientific journals. The time frame for the project is 2010 – 2013. This project was originally submitted as an intramural research project to the National Occupational Research Agenda (NORA) program. The project proposal was reviewed and strongly recommended for funding by both internal NIOSH and external peer reviewers. The NIOSH Office of the Director has authorized that the project proceed and that a protocol be submitted to the NIOSH Human Subjects Review Board (HSRB) for approval. The text of the original NORA study proposal is contained in the reformatted protocol to meet HSRB protocol format requirements. Information required for the initial proposal but not pertinent to this protocol (i.e., detailed study budget, and the Curriculum Vitae of project collaborators) have been removed. Cancer_Study_Protocol_web_ready.pdf
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