Reduced evolutionary rate in reemerged Ebola virus transmission chains

Details

• Alternative Title:
  Sci Adv
• Personal Author:
  Blackley, David J. ; Wiley, Michael R. ; Ladner, Jason T. ; Fallah, Mosoka ; Lo, Terrence ; Gilbert, Merle L. ; Gregory, Christopher ; D’ambrozio, Jonathan ; Coulter, Stewart ; Mate, Suzanne ; Balogun, Zephaniah ; Kugelman, Jeffrey ; Nwachukwu, William ; Prieto, Karla ; Yeiah, Adolphus ; Amegashie, Fred ; Kearney, Brian ; Wisniewski, Meagan ; Saindon, John ; Schroth, Gary ; Fakoli, Lawrence ; Diclaro, Joseph W. ; Kuhn, Jens H. ; Hensley, Lisa E. ; Jahrling, Peter B. ; Ströher, Ute ; Nichol, Stuart T. ; Massaquoi, Moses ; Kateh, Francis ; Clement, Peter ; Gasasira, Alex ; Bolay, Fatorma ; Monroe, Stephan S. ; Rambaut, Andrew ; Sanchez-Lockhart, Mariano ; Scott Laney, A. ; Nyenswah, Tolbert ; Christie, Athalia ; Palacios, Gustavo
• Description:
  On 29 June 2015, Liberia's respite from Ebola virus disease (EVD) was interrupted for the second time by a renewed outbreak ("flare-up") of seven confirmed cases. We demonstrate that, similar to the March 2015 flare-up associated with sexual transmission, this new flare-up was a reemergence of a Liberian transmission chain originating from a persistently infected source rather than a reintroduction from a reservoir or a neighboring country with active transmission. Although distinct, Ebola virus (EBOV) genomes from both flare-ups exhibit significantly low genetic divergence, indicating a reduced rate of EBOV evolution during persistent infection. Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over.
• Subjects:
  Ebolavirus Hemorrhagic Fever, Ebola
• Source:
  Sci Adv. 2016; 2(4).
• Pubmed ID:
  27386513
• Pubmed Central ID:
  PMC4928956
• Document Type:
  Journal Article
• Place as Subject:
  Africa, Western ; Liberia
• Volume:
  2
• Issue:
  4
• NIOSHTIC Number:
  nn:20048360
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:011b820f82c58dd9137ef5aea960d3bc970837f3165a2bce8f5f46d6012a597524d1c8ca602b356c7b4e3f12273a3de81a56af34036ba0985efbd62157c00270
• Download URL:
  https://stacks.cdc.gov/view/cdc/40623/cdc_40623_DS1.pdf
• File Type:
  [PDF - 804.36 KB ]