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Clinical Research and the Training of Host Country Investigators: Essential Health Priorities for Disease-Endemic Regions
Filetype[PDF - 564.13 KB]


Details:
  • Pubmed ID:
    26598570
  • Pubmed Central ID:
    PMC4751934
  • Funding:
    FD-R-01-001692/FD/FDA HHS/United States
    FD-R-01-003373/FD/FDA HHS/United States
    P50 AI 39469/AI/NIAID NIH HHS/United States
    R01 AI 110386/AI/NIAID NIH HHS/United States
    R01 AI 25136/AI/NIAID NIH HHS/United States
    R21 AI 074058/AI/NIAID NIH HHS/United States
    R21 AI074058/AI/NIAID NIH HHS/United States
    U01 CI 000211/CI/NCPDCID CDC HHS/United States
    U19 AI 089696/AI/NIAID NIH HHS/United States
    U19 AI089696/AI/NIAID NIH HHS/United States
    UM1 AI 69471/AI/NIAID NIH HHS/United States
    UM1 AI069471/AI/NIAID NIH HHS/United States
    UR3/CCU 418652/PHS HHS/United States
    Intramural NIH HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    The health-care needs and resources of disease-endemic regions such as west Africa have been a major focus during the recent Ebola outbreak. On the basis of that experience, we call attention to two priorities that have unfortunately been ignored thus far: 1) the development of clinical research facilities and 2) the training of host country investigators to ensure that the facilities and expertise necessary to evaluate candidate interventions are available on-site in endemic regions when and where they are needed. In their absence, as illustrated by the recent uncertainty about the use of antivirals and other interventions for Ebola virus disease, the only treatment available may be supportive care, case fatality rates may be unacceptably high and there may be long delays between the time potential interventions become available and it becomes clear whether those interventions are safe or effective. On the basis of our experience in Mali, we urge that the development of clinical research facilities and the training of host country investigators be prioritized in disease-endemic regions such as west Africa.