Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Details

• Alternative Title:
  Nat Commun
• Personal Author:
  Machiela, Mitchell J. ; Zhou, Weiyin ; Karlins, Eric ; Sampson, Joshua N. ; Freedman, Neal D. ; Yang, Qi ; Hicks, Belynda ; Dagnall, Casey ; Hautman, Christopher ; Jacobs, Kevin B. ; Abnet, Christian C. ; Aldrich, Melinda C. ; Amos, Christopher ; Amundadottir, Laufey T. ; Arslan, Alan A. ; Beane-Freeman, Laura E. ; Berndt, Sonja I. ; Black, Amanda ; Blot, William J. ; Bock, Cathryn H. ; Bracci, Paige M. ; Brinton, Louise A. ; Bueno-de-Mesquita, H Bas ; Burdett, Laurie ; Buring, Julie E. ; Butler, Mary A. ; Canzian, Federico ; Carreón, Tania ; Chaffee, Kari G. ; Chang, I-Shou ; Chatterjee, Nilanjan ; Chen, Chu ; Chen, Constance ; Chen, Kexin ; Chung, Charles C. ; Cook, Linda S. ; Crous Bou, Marta ; Cullen, Michael ; Davis, Faith G. ; De Vivo, Immaculata ; Ding, Ti ; Doherty, Jennifer ; Duell, Eric J. ; Epstein, Caroline G. ; Fan, Jin-Hu ; Figueroa, Jonine D. ; Fraumeni, Joseph F. ; Friedenreich, Christine M. ; Fuchs, Charles S. ; Gallinger, Steven ; Gao, Yu-Tang ; Gapstur, Susan M. ; Garcia-Closas, Montserrat ; Gaudet, Mia M. ; Gaziano, J. Michael ; Giles, Graham G. ; Gillanders, Elizabeth M. ; Giovannucci, Edward L. ; Goldin, Lynn ; Goldstein, Alisa M. ; Haiman, Christopher A. ; Hallmans, Goran ; Hankinson, Susan E. ; Harris, Curtis C. ; Henriksson, Roger ; Holly, Elizabeth A. ; Hong, Yun-Chul ; Hoover, Robert N. ; Hsiung, Chao A. ; Hu, Nan ; Hu, Wei ; Hunter, David J. ; Hutchinson, Amy ; Jenab, Mazda ; Johansen, Christoffer ; Khaw, Kay-Tee ; Kim, Hee Nam ; Kim, Yeul Hong ; Kim, Young Tae ; Klein, Alison P. ; Klein, Robert ; Koh, Woon-Puay ; Kolonel, Laurence N. ; Kooperberg, Charles ; Kraft, Peter ; Krogh, Vittorio ; Kurtz, Robert C. ; LaCroix, Andrea ; Lan, Qing ; Landi, Maria Teresa ; Marchand, Loic Le ; Li, Donghui ; Liang, Xiaolin ; Liao, Linda M. ; Lin, Dongxin ; Liu, Jianjun ; Lissowska, Jolanta ; Lu, Lingeng ; Magliocco, Anthony M. ; Malats, Nuria ; Matsuo, Keitaro ; McNeill, Lorna H. ; McWilliams, Robert R. ; Melin, Beatrice S. ; Mirabello, Lisa ; Moore, Lee ; Olson, Sara H. ; Orlow, Irene ; Park, Jae Yong ; Patiño-Garcia, Ana ; Peplonska, Beata ; Peters, Ulrike ; Petersen, Gloria M. ; Pooler, Loreall ; Prescott, Jennifer ; Prokunina-Olsson, Ludmila ; Purdue, Mark P. ; Qiao, You-Lin ; Rajaraman, Preetha ; Real, Francisco X. ; Riboli, Elio ; Risch, Harvey A. ; Rodriguez-Santiago, Benjamin ; Ruder, Avima M. ; Savage, Sharon A. ; Schumacher, Fredrick ; Schwartz, Ann G. ; Schwartz, Kendra L. ; Seow, Adeline ; Wendy Setiawan, Veronica ; Severi, Gianluca ; Shen, Hongbing ; Sheng, Xin ; Shin, Min-Ho ; Shu, Xiao-Ou ; Silverman, Debra T. ; Spitz, Margaret R. ; Stevens, Victoria L. ; Stolzenberg-Solomon, Rachael ; Stram, Daniel ; Tang, Ze-Zhong ; Taylor, Philip R. ; Teras, Lauren R. ; Tobias, Geoffrey S. ; Van Den Berg, David ; Visvanathan, Kala ; Wacholder, Sholom ; Wang, Jiu-Cun ; Wang, Zhaoming ; Wentzensen, Nicolas ; Wheeler, William ; White, Emily ; Wiencke, John K. ; Wolpin, Brian M. ; Wong, Maria Pik ; Wu, Chen ; Wu, Tangchun ; Wu, Xifeng ; Wu, Yi-Long ; Wunder, Jay S. ; Xia, Lucy ; Yang, Hannah P. ; Yang, Pan-Chyr ; Yu, Kai ; Zanetti, Krista A. ; Zeleniuch-Jacquotte, Anne ; Zheng, Wei ; Zhou, Baosen ; Ziegler, Regina G. ; Perez-Jurado, Luis A. ; Caporaso, Neil E. ; Rothman, Nathaniel ; Tucker, Margaret ; Dean, Michael C. ; Yeager, Meredith ; Chanock, Stephen J.
• Description:
  To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases.
• Subjects:
  Aging Chromosomes, Human, X DNA Methylation Female Humans Male Mosaicism Polymerase Chain Reaction Reproducibility Of Results X Chromosome Inactivation
• Source:
  Nat Commun. 2016; 7.
• Pubmed ID:
  27291797
• Pubmed Central ID:
  PMC4909985
• Document Type:
  Journal Article
• Volume:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:16e5f78f92f280ca999d2c5240d3b6fbd3645605a28e993c6d54b5cad40d9a87
• Download URL:
  https://stacks.cdc.gov/view/cdc/40463/cdc_40463_DS1.pdf
• File Type:
  [PDF - 455.92 KB ]